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npj Regenerative Medicine

npj Regenerative Medicine

IF: 6.5
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Genetic compensation response contributes to Pleurodeles waltl limb regeneration

Published:31 May 2025 DOI: 10.1038/s41536-025-00417-y PMID: 40450023
Binxu Yin,?Changhao Yu,?Yang Liu,?Hao Cai,?Wencheng Wu,?Tingting Ye,?Lei Wang,?Lujia Xiao,?Yi Zhu,?Huaijuan Guo,?Kun Zhang,?Heng Wang

Abstract

Hippo-Yap/Taz pathway is essential for tissue regeneration in multiple species. However, we found that in the highly regenerative salamanders, Yap knockout does not compromise the limb regeneration due to genetic compensation response (GCR). Specifically, the mutated Yap locus derived non-sense mRNA, which was recognized by UPF3A to instruct compensatory Taz induction. Blocking Yap mRNA or protein indeed inhibits regeneration. GCR could be utilized to maintain the robustness of limb regeneration.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Verteporfin 129497-78-5 2C41H42N4O8 253 suppliers $24.00-$5308.00
Verteporfin 129497-78-5 2C41H42N4O8 253 suppliers $24.00-$5308.00
Verteporfin 129497-78-5 2C41H42N4O8 253 suppliers $24.00-$5308.00
Verteporfin 129497-78-5 2C41H42N4O8 253 suppliers $24.00-$5308.00

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