一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Phytomedicine >>article
Phytomedicine

Phytomedicine

IF: 6.7
Download PDF

Structure-affinity driven repurposing of natural compounds and herbal prescriptions for ulcerative colitis and psoriasis

Published:23 June 2025 DOI: 10.1016/j.phymed.2025.156999
Rui Tian , Ting Hu , Jinyuan Chang , Xue Chen , Zhenglong Jiang , Xuanyi Wang , Li Feng , Shaosheng Bei

Abstract

Background

Psoriasis and ulcerative colitis (UC) are immune-mediated chronic inflammatory diseases that affect barrier organs and share significant overlap in both pathogenesis and treatment strategies. Although the advent of biologics has transformed therapeutic options, their high cost often limits long-term accessibility, underscoring the need for alternative approaches.

Purpose

Natural compounds and traditional medicine represent valuable sources for novel drug discovery and repurposing, but systematic strategies for repurposing traditional medicines remain underdeveloped.

Methods

Here, we present a computational framework for drug repurposing based on drug-target affinity and structural rationality, focused on the traditional herbs and prescriptions of JAK family and chemokine receptors.

Results

We identified 204 natural compounds, among which 9-hydroxycamptothecin showed the most promising therapeutic potential for both psoriasis and UC. Notably, WU MEI PILL, a classical prescription in East Asian traditional medicine, also emerged as a promising multi-target therapy for both diseases. In vivo experiments confirmed that 9-hydroxycamptothecin and WU MEI PILL significantly alleviated disease symptoms, improved intestinal mucosal and epidermal pathologies, and upregulated intestinal Claudin-1 and MUC-2 expression. These effects were mediated through suppression of JAK1/STAT3 phosphorylation.

Conclusion

This study introduces a tailored approach for traditional medicine-based drug repurposing, offering a scalable and efficient strategy for identifying natural therapeutics and guiding clinical decision-making, modernization, and standardization of traditional medicine.

凤凰县| 台中县| 宁国市| 手游| 泰来县| 瑞金市| 平原县| 兴和县| 永城市| 柯坪县| 延川县| 阜新市| 武平县| 扎鲁特旗| 囊谦县| 巴里| 武平县| 永靖县| 建平县| 根河市| 略阳县| 民乐县| 桐城市| 邵阳县| 塔河县| 浮梁县| 秦皇岛市| 西青区| 同德县| 易门县| 长武县| 昌乐县| 昌黎县| 色达县| 无棣县| 东乌珠穆沁旗| 天津市| 祁门县| 达日县| 宁晋县| 万安县|