一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Cell Death and Differentiation >>article
Cell Death and Differentiation

Cell Death and Differentiation

IF: 15.4
Download PDF

ABCC10-mediated cGAMP efflux drives cancer cell radiotherapy resistance

Published:6 August 2025 DOI: 10.1038/s41418-025-01552-1
Zhengyang Zhang, Jie Gao, Xiang Liao, Zining Zhang, Xiongfeng Cao, Yi Gong, Wenlong Chen, Lirong Zhang, Hsiang-i Tsai, Dongqing Wang, Haitao Zhu

Abstract

Although radiotherapy (RT) is used in more than 50% of cancer patients, the intrinsic radioresistance of cancer cells, characterized by metabolic adaptation, significantly limits its clinical efficacy. However, the mechanisms underlying RT resistance (RTR) remain incompletely understood. In this study, we used high-throughput metabolic CRISPR library screening and identified ABCC10 as a novel molecular contributor to RTR. Functional assays, including vesicle transport, molecular docking, and an enzyme-linked immunosorbent assay, confirmed that the R545 site of ABCC10 binds to and effluxes 2′3′-cyclic GMP–AMP (cGAMP) in an ATP-dependent manner. Mechanistically, RNA transcriptomics, along with overexpression and silencing experiments, demonstrated that ABCC10-mediated export of cGAMP suppresses the STING-TBK1-IRF3 signaling pathway. This efflux reduces RT-induced intercellular accumulation of reactive oxygen species and DNA damage. In vivo, a combination of RT and nilotinib, a potential ABCC10 inhibitor, synergistically inhibited tumor growth. In summary, we identified ABCC10 as a novel exporter of cGAMP in RTR. Our results highlight its potential role as a biomarker for predicting RT response and as a therapeutic target for overcoming RTR.

Substances (14)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Lapatinib 231277-92-2 C29H26ClFN4O4S 572 suppliers $10.00-$1900.00
Lapatinib 231277-92-2 C29H26ClFN4O4S 572 suppliers $10.00-$1900.00
Lapatinib 231277-92-2 C29H26ClFN4O4S 572 suppliers $10.00-$1900.00
Lapatinib 231277-92-2 C29H26ClFN4O4S 572 suppliers $10.00-$1900.00
Nilotinib 641571-10-0 C28H22F3N7O 511 suppliers $10.00-$1827.00
Nilotinib 641571-10-0 C28H22F3N7O 511 suppliers $10.00-$1827.00
Nilotinib 641571-10-0 C28H22F3N7O 511 suppliers $10.00-$1827.00
Nilotinib 641571-10-0 C28H22F3N7O 511 suppliers $10.00-$1827.00
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea 941987-60-6 C17H17N3O 113 suppliers $9.79-$1872.00
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea 941987-60-6 C17H17N3O 113 suppliers $9.79-$1872.00

Similar articles

IF:3.9

Detection of β-lactamase-mediated resistance

Journal of Antimicrobial Chemotherapy D. Livermore,?Derek F. J. Brown,etc Published: 1 July 2001
平度市| 青神县| 奉节县| 施甸县| 成安县| 彭山县| 阳谷县| 正蓝旗| 汉源县| 吉木萨尔县| 安乡县| 新晃| 海林市| 凯里市| 大厂| 繁昌县| 比如县| 松溪县| 温州市| 洪湖市| 禹城市| 寿宁县| 奈曼旗| 静海县| 浦县| 文登市| 徐闻县| 宁远县| 康乐县| 唐河县| 芮城县| 华宁县| 亳州市| 长春市| 江油市| 通州市| 榕江县| 锡林郭勒盟| 普安县| 太和县| 贵州省|