一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Biochemical and biophysical research communications >>article
Biochemical and biophysical research communications

Biochemical and biophysical research communications

IF: 2.5
Download PDF

Adrenic acid suppresses liver regeneration by inhibiting Serpina1c expression

Published:11 August 2025 DOI: 10.1016/j.bbrc.2025.152477
Ying Chen , Yue-Jie Xu , Rong Zhang , Cai-Zhi Liu , Cheng Hu

Abstract

Diminished hepatocyte regeneration constitutes a fundamental pathological feature in chronic liver diseases. While elevated adrenic acid (ADA) has recently been implicated in chronic hepatopathies, its direct regulatory role in liver regeneration remained undefined. Here, we examined the effect of ADA on hepatocyte proliferation and liver regeneration. Using a murine partial hepatectomy (PHx) model, we found that systemic administration of ADA significantly impaired liver regeneration, evidenced by reduced liver-to-body weight ratios and fewer Ki67-positive hepatocytes. Mechanistically, transcriptomic analysis identified Serpina1c as a key downstream target suppressed by ADA. In vitro, ADA directly inhibited AML12 hepatocyte proliferation, an effect that was completely rescued by the overexpression of Serpina1c. Conclusively, ADA-mediated Serpina1c inhibition suppresses hepatic regeneration, while restoring its function rescues this defect, suggesting a molecularly precise therapeutic strategy.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
ADRENIC ACID 28874-58-0 C22H36O2 83 suppliers $28.00-$1045.28
ADRENIC ACID 28874-58-0 C22H36O2 83 suppliers $28.00-$1045.28
ADRENIC ACID 28874-58-0 C22H36O2 83 suppliers $28.00-$1045.28
ADRENIC ACID 28874-58-0 C22H36O2 83 suppliers $28.00-$1045.28

Similar articles

IF:6

PhNH10 Suppresses Low Temperature Tolerance in Petunia Through the Abscisic Acid‐Dependent Pathway

Plant, Cell & Environment Hongzhuang Niu, Xueqi Liu,etc Published: 20 November 2024
IF:5.2

L-Histidine attenuates NEFA-induced inflammatory responses by suppressing Gab2 expression

Life sciences Mengze Li , Huiying Wang ,etc Published: 4 May 2024
IF:4.6

Glycyrrhizic acid in the treatment of liver diseases: literature review.

ACS Applied Bio Materials Jian-yuan Li, Hong-yan Cao,etc Published: 1 January 2014
克东县| 甘德县| 天长市| 保亭| 苏州市| 丹棱县| 阳曲县| 平远县| 天峻县| 岑巩县| 金昌市| 威宁| 印江| 巴彦淖尔市| 青阳县| 遂平县| 盱眙县| 曲阳县| 五峰| 淅川县| 开江县| 灌云县| 彰化县| 遂溪县| 澎湖县| 遂溪县| 收藏| 白玉县| 门头沟区| 淮南市| 合作市| 江山市| 新龙县| 南康市| 旬邑县| 天长市| 即墨市| 黔江区| 南充市| 龙里县| 什邡市|