一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Langmuir >>article
Langmuir

Langmuir

IF: 3.7
Download PDF

Vitamin-Integrated PROTAC Nanoparticle for Combined Therapy of NSCLC

Published:14 August 2025 DOI: 10.1021/acs.langmuir.5c01856
Bolin Yue, Tingli Wang, Mengke Zhang, Xiaoyu Wu, Xu Xu*, Zequan Li, Bohan Ye, Lei Liu* and Shiyong Song*, 

Abstract

Proteolysis-targeting chimeric (PROTAC) technology represents a groundbreaking approach with immense potential for treating a wide range of diseases. However, its clinical application is often limited by challenges in solubility and permeability. Herein, we have developed an innovative three-in-one nanoparticulate therapeutic agent tailored for non-small-cell lung cancer (NSCLC). This agent features a PROTAC molecule derived from ceritinib, designated as 27B, serving as a targeted degrader of anaplastic lymphoma kinase (ALK). 27B is self-assembled with vitamin A palmitate (VAP) and vitamin E poly(ethylene glycol) succinate (TPGS) to form stable nanoparticles (BVT-NPs) that exhibit a uniform spherical morphology, excellent storage stability, and robust plasma stability. With an average particle size of approximately 130 nm and a loading capacity of 27B of 20%, BVT-NPs demonstrate a pH-responsive drug release profile. In vitro studies reveal that BVT-NPs significantly inhibit the proliferation of H3122 cells more effectively than free 27B, indicating a synergistic antitumor effect. Western blot analysis further confirms the superior efficacy of BVT-NPs in downregulating ALK and P-glycoprotein and upregulating Caspase-3. BVT-NPs markedly suppress tumor growth without inducing significant tissue toxicity. This carrier-free, multifunctional nanoparticulate system integrates PROTAC-mediated protein degradation with chemotherapy, thereby improving the PROTAC absorption and generating a synergistic therapeutic effect against NSCLC.

Similar articles

IF:0

Combined Upper Limb Exercise and Creatine Monohydrate Supplementation Improved Musculoskeletal Function in NSCLC Patients

Jurnal Respirologi Indonesia Muhammad Addinul Huda, A. Setijadi,etc Published: 5 September 2022
IF:9.4

Co-delivery of vitamin and amino acid within MOFs for oxidative stress-based tumor gas therapy

Journal of Colloid and Interface Science Xueping Yan, Peng Jing,etc Published: 19 November 2024
宁陕县| 平原县| 临沧市| 天镇县| 鹰潭市| 临沧市| 汝州市| 清流县| 自治县| 颍上县| 垫江县| 靖边县| 昌江| 永新县| 积石山| 上饶市| 佛山市| 奉节县| 富源县| 翁牛特旗| 武威市| 锡林郭勒盟| 台南县| 紫云| 沙湾县| 兴海县| 德昌县| 宾阳县| 新干县| 灌云县| 北川| 罗平县| 郑州市| 普兰店市| 溧水县| 河北区| 湾仔区| 上高县| 苏尼特左旗| 新民市| 博湖县|