一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Molecules >>article
Molecules

Molecules

IF: 4.2
Download PDF

Bufalin Suppresses Colorectal Cancer Liver Metastasis by Inhibiting De Novo Fatty Acid Synthesis via the PI3K/AKT-Mediated SREBP1/FASN Pathway

Published:5 September 2025 DOI: 10.3390/molecules30173634 PMID: 40942159
Wenwen Pang,?Xiang Li,?Suying Yan,?Junshi Zhang,?Ping Wu,?Haiyang Yu,?Bowei Zhang,?Chunze Zhang

Abstract

Background: Colorectal cancer (CRC) is the third most common cancer worldwide, with liver metastasis being the leading cause of mortality. De novo fatty acid synthesis plays a critical role in CRC progression and metastasis. Bufalin, a cardiotonic steroid isolated from toad skin, has demonstrated anticancer activity in multiple preclinical models. However, the mechanisms underlying its suppression of CRC metastasis and modulation of fatty acid synthesis remain to be elucidated.

Methods: The effects of bufalin on CRC cell proliferation, migration, and apoptosis were assessed via colony formation, wound healing, and flow cytometry assays. Transcriptome analysis identified bufalin-affected pathways, with changes in gene and protein expression. FASN protein levels were quantified using ELISA.

Results: Bufalin inhibited proliferation and migration of CRC cells and induced the apoptosis of LoVo and HCT8 cells. Transcriptome analysis highlighted lipid metabolism pathways as potential mediators of bufalin's anti-metastatic activity. Notably, bufalin reduced the expression of fatty acid synthase (FASN) and suppressed CRC metastasis. In vivo experiments demonstrated that bufalin attenuated CRC progression and liver metastasis by inhibiting de novo fatty acid synthesis through the PI3K/AKT-mediated SREBP1/FASN pathway.

Conclusions: Bufalin inhibits de novo fatty acid synthesis via the PI3K/AKT-mediated SREBP1/FASN pathway, suppressing CRC progression and liver metastasis.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Bufalin 465-21-4 C24H34O4 284 suppliers $31.00-$2900.00
Bufalin 465-21-4 C24H34O4 284 suppliers $31.00-$2900.00
Bufalin 465-21-4 C24H34O4 284 suppliers $31.00-$2900.00
Bufalin 465-21-4 C24H34O4 284 suppliers $31.00-$2900.00

Similar articles

IF:4.2

Tianeptine sodium salt suppresses TNF-α-induced expression of matrix metalloproteinase-9 in human carcinoma cells via suppression of the PI3K/Akt-mediated NF-κB pathway

Environmental toxicology and pharmacology Rajapaksha Gedara Prasad Tharanga Jayasooriya , Matharage Gayani Dilshara ,etc Published: 1 September 2014
IF:5.7

The transdermal cream of Formestane anti-breast cancer by controlling PI3K-Akt pathway and the tumor immune microenvironment.

Frontiers in Immunology Lanyang Gao, Lei Zhu,etc Published: 1 January 2023
玉门市| 扶沟县| 肃南| 扎赉特旗| 英山县| 马尔康县| 麻栗坡县| 兴和县| 嫩江县| 太仆寺旗| 永吉县| 乌鲁木齐县| 凭祥市| 钦州市| 永新县| 灵寿县| 石城县| 英超| 上思县| 胶南市| 察雅县| 东丰县| 临潭县| 虞城县| 清河县| 壶关县| 寻乌县| 岳阳县| 巴塘县| 遂宁市| 安塞县| 称多县| 镇赉县| 云梦县| 阳谷县| 乐平市| 陆河县| 邹城市| 枝江市| 淮滨县| 天台县|