一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of Agricultural and Food Chemistry >>article
Journal of Agricultural and Food Chemistry

Journal of Agricultural and Food Chemistry

IF: 5.7
Download PDF

Licochalcone D Alleviates Radiation-Induced Intestinal Injury via SIRT3-Dependent Mitophagy: A Natural Phytochemical Strategy for Radioprotection

Published:1 October 2025 DOI: 10.1021/acs.jafc.5c05399
Jiaxin Zhang, , , Shengjie Ma, , , Zhen Wang, , , Pai Wang, , , Heshi Liu, , and , Quan Wang*, 

Abstract

Oxidative stress, a key mechanism in radiation-induced intestinal injury (RIII), is triggered by ionizing radiation. Licochalcone D (LCD), a bioactive compound derived from licorice, exhibits potent antioxidant properties, yet its role and mechanism in RIII remain unclear. In this study, in vitro experiments revealed that the pretreatment of intestinal epithelial cells with LCD significantly enhanced cell viability, reduced radiation-induced DNA breaks, and suppressed reactive oxygen species (ROS) accumulation. In vivo, LCD administration mitigated radiation-induced body weight loss, preserved intestinal crypt integrity, and attenuated villous damage in irradiated mice. Mechanistically, LCD stabilizes SIRT3 protein to activate mitophagy, thereby eliminating radiation-generated ROS and subsequently alleviating DNA damage and preventing cell apoptosis. These findings broaden the potential applications of LCD in protecting against RIII and establish the SIRT3-mitophagy axis as a novel pharmacological target for preventing radiation-induced intestinal damage.

Substances (12)

Materials
Procduct Name CAS Molecular Formula Supplier Price
CHLOROQUINE 54-05-7 C18H26ClN3 219 suppliers $5.00-$1550.00
CHLOROQUINE 54-05-7 C18H26ClN3 219 suppliers $5.00-$1550.00
CHLOROQUINE 54-05-7 C18H26ClN3 219 suppliers $5.00-$1550.00
CHLOROQUINE 54-05-7 C18H26ClN3 219 suppliers $5.00-$1550.00
Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI) 120241-79-4 C7H6N4 109 suppliers $10.00-$2556.00
Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI) 120241-79-4 C7H6N4 109 suppliers $10.00-$2556.00
Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI) 120241-79-4 C7H6N4 109 suppliers $10.00-$2556.00
Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI) 120241-79-4 C7H6N4 109 suppliers $10.00-$2556.00
2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)- 144506-15-0 C21H22O5 104 suppliers Inquiry
2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)- 144506-15-0 C21H22O5 104 suppliers Inquiry

Similar articles

IF:5.3

The Mitochondrial-Derived Peptide MOTS-c Alleviates Radiation Pneumonitis via an Nrf2-Dependent Mechanism

ACS Applied Nano Materials Yanli Zhang, Jianfeng Huang,etc Published: 17 May 2024
IF:3.7

Acesulfame potassium induces dysbiosis and intestinal injury with enhanced lymphocyte migration to intestinal mucosa

Journal of Gastroenterology and Hepatology Yoshinori Hanawa, Masaaki Higashiyama,etc Published: 8 August 2021
IF:6.7

Phytochemicals: A potential next generation agent for radioprotection

Phytomedicine Bimal Prasad Jit , Subhaswaraj Pattnaik ,etc Published: 1 November 2022
方山县| 闽侯县| 安陆市| 克什克腾旗| 青阳县| 望城县| 泰兴市| 栾川县| 克什克腾旗| 精河县| 宜昌市| 光山县| 剑河县| 南京市| 常德市| 抚宁县| 南靖县| 安仁县| 贵港市| 台中市| 湘潭县| 崇州市| 图木舒克市| 宁陕县| 长武县| 自贡市| 龙陵县| 昭平县| 汝城县| 肥城市| 锦州市| 大城县| 密云县| 康马县| 郯城县| 临夏县| 三门峡市| 广饶县| 洮南市| 孙吴县| 潼南县|