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The m6A reader IGF2BP2 promotes homologous recombination-mediated DNA repair by eliminating DNA-RNA hybrids

Published:28 October 2025 DOI: 10.1016/j.celrep.2025.116438 PMID: 41100254
Yating Sun,?Haojie Zhang,?Shiwei Li,?Jinzhi Zhang,?Bin Lyu,?Liping Kang,?Xinkun Teng,?Mingwei Yin,?Weidong Peng,?Jingjing Wang,?Zhimin Chu,?Chengying Cui,?Dejie Kong,?Mingqing Wu,?Yongqiang Wang,?Jiadong Wang,?Yang Li

Abstract

Double-strand breaks (DSBs) are among the most deleterious forms of DNA damage and are precisely repaired through homologous recombination (HR). DNA-RNA hybrids formed at DSB sites play a critical role in HR-mediated repair and must be tightly regulated. Here, we identify the m6A reader IGF2BP2, together with the RNA helicase DHX9, as key factors recruited to DSBs that remove DNA-RNA hybrids in an m6A-dependent manner. This axis prevents hybrid accumulation, enables RAD51 loading, and promotes HR-mediated repair. Loss of IGF2BP2 sensitizes cancer cells and xenograft tumors to DNA damage-inducing therapies, revealing therapeutic implications.

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Procduct Name CAS Molecular Formula Supplier Price
Cisplatin 15663-27-1 Cl2H6N2Pt 921 suppliers $17.00-$7570.00
Cisplatin 15663-27-1 Cl2H6N2Pt 921 suppliers $17.00-$7570.00
Cisplatin 15663-27-1 Cl2H6N2Pt 921 suppliers $17.00-$7570.00
Cisplatin 15663-27-1 Cl2H6N2Pt 921 suppliers $17.00-$7570.00
Cisplatin 15663-27-1 - Inquiry
Cisplatin 15663-27-1 - Inquiry

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