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Cell and Bioscience

Cell and Bioscience

IF: 6.1
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Breaking the link between morphology and potency for mESCs

Published:23 October 2025 DOI: 10.1186/s13578-025-01497-5 PMID: 41131638
Yixin Fan,?Xiaomin Wang,?Ziwei Zhai,?Tao Huang,?Wei Li,?Zechuan Liang,?Zhaoyi Ma,?Yu Fu,?Pengli Li,?Junqi Kuang,?Duanqing Pei

Abstract

Background: In stem cell biology, a long-held structure-function relationship is the domed colony morphology and na?ve pluripotency for mouse or human pluripotent stem cells. This link has provided a convenient way to recognize bona fide na?ve pluripotent cells during derivation, passaging and characterization. However, the molecular basis of this link remains poorly understood.

Results: We show that a loss of domed morphology may not impact the overall genetic architecture of na?ve pluripotency in mouse embryonic stem cells (mESCs). We first generated stable mESC lines by knocking out Myh9 that encodes non-muscle myosin heavy chain IIA, resulting in colonies deprived of the typical domed morphology, but competent to differentiate into the three germ layers and chimeric mice. Modulating cell morphologies with inhibitors against kinases known to regulate myosin pathway also phenocopy the knockout in wild type mESCs.

Conclusions: These results provide evidence that the domed morphology and potency can be uncoupled and suggest that domed structure is not a pre-requisite for acquiring and maintaining na?ve pluripotency.

Substances (26)

Materials
Procduct Name CAS Molecular Formula Supplier Price
2-Deoxy-D-glucose 154-17-6 C6H12O5 735 suppliers $6.00-$3350.00
2-Deoxy-D-glucose 154-17-6 C6H12O5 735 suppliers $6.00-$3350.00
2-Deoxy-D-glucose 154-17-6 C6H12O5 735 suppliers $6.00-$3350.00
2-Deoxy-D-glucose 154-17-6 C6H12O5 735 suppliers $6.00-$3350.00
CHIR-99021 252917-06-9 C22H18Cl2N8 340 suppliers $28.00-$4401.00
CHIR-99021 252917-06-9 C22H18Cl2N8 340 suppliers $28.00-$4401.00
CHIR-99021 252917-06-9 C22H18Cl2N8 340 suppliers $28.00-$4401.00
CHIR-99021 252917-06-9 C22H18Cl2N8 340 suppliers $28.00-$4401.00
PD 0325901 391210-10-9 C16H14F3IN2O4 281 suppliers $8.00-$3990.00
PD 0325901 391210-10-9 C16H14F3IN2O4 281 suppliers $8.00-$3990.00

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