一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Biomaterials >>article
Biomaterials

Biomaterials

IF: 12.8
Download PDF

Multifaceted roles of a bioengineered nanoreactor in repressing radiation-induced lung injury

Published:1 October 2021 DOI: 10.1016/j.biomaterials.2021.121103 PMID: 34478930
Tao Liu , Qunfang Yang , Haiping Zheng , Honglin Jia , Yufeng He , Xuan Zhang , Junfeng Zheng , Yue Xi , Haigang Zhang , Renshan Sun , Xiaohong Chen , Wenjun Shan

Abstract

Radiation‐induced lung injury (RILI) is a potentially fatal and dose-limiting complication of thoracic cancer radiotherapy. However, effective therapeutic agents for this condition are limited. Here, we describe a novel strategy to exert additive effects of a non-erythropoietic EPO derivative (ARA290), along with a free radical scavenger, superoxide dismutase (SOD), using a bioengineered nanoreactor (SOD@ARA290-HBc). ARA290-chimeric nanoreactor makes SOD present in a confined reaction space by encapsulation into its interior to heighten stability against denaturing stimuli. In a RILI mouse model, intratracheal administration of SOD@ARA290-HBc was shown to significantly ameliorate acute radiation pneumonitis and pulmonary fibrosis. Our investigations revealed that SOD@ARA290-HBc performs its radioprotective effects by protecting against radiation induced alveolar epithelial cell apoptosis and ferroptosis, suppressing oxidative stress, inhibiting inflammation and by modulating the infiltrated macrophage phenotype, or through a combination of these mechanisms. In conclusion, SOD@ARA29-HBc is a potential therapeutic agent for RILI, and given its multifaceted roles, it may be further developed as a translational nanomedicine for other related disorders.

Substances (2)

Materials
Procduct Name CAS Molecular Formula Supplier Price
JC-10 5563-28-0 C25H29Cl2N4.I 56 suppliers Inquiry
JC-10 5563-28-0 C25H29Cl2N4.I 56 suppliers Inquiry

Similar articles

IF:3.7

Curcumin and Especially Tetrahydrocurcumin Ameliorate Oxidative Stress-Induced Renal Injury in Mice

Journal of Nutrition Okada Kunihiko , Wangpoengtrakul Chantima ,etc Published: 1 August 2001
IF:0.7

Alfacalcidol-Induced Kidney Injury in Patients with Severe Motor and Intellectual Disabilities.

Journal of nutritional science and vitaminology Osamu Uemura,?Yuka Hasegawa,etc Published: 1 January 2024
西乌珠穆沁旗| 观塘区| 桂林市| 秀山| 寻甸| 邢台县| 大宁县| 兰溪市| 高唐县| 泰兴市| 利辛县| 郎溪县| 高淳县| 准格尔旗| 西华县| 金溪县| 漳州市| 康平县| 白朗县| 凤山县| 兰西县| 寻甸| 资兴市| 遂昌县| 中西区| 贵溪市| 峨山| 英山县| 北京市| 深水埗区| 平顶山市| 开化县| 蕉岭县| 永和县| 信宜市| 井陉县| 桐庐县| 济源市| 蕉岭县| 惠水县| 安西县|