一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Chemosphere >>article
Chemosphere

Chemosphere

IF: 8.1
Download PDF

Ivermectin confers its cytotoxic effects by inducing AMPK/mTOR-mediated autophagy and DNA damage.

Published:1 November 2020 DOI: 10.1016/j.chemosphere.2020.127448 PMID: 32593828
Ping Zhang , Hongfei Ni , Yang Zhang , Wenping Xu , Jufang Gao , Jiagao Cheng , Liming Tao

Abstract

Ivermectin (IVM), a broad-spectrum antiparasitic drug, is widely used in agriculture and animal husbandry. Due to widespread use and little metabolism in animals, the toxicity of IVM has received increasing attention. The accumulation of IVM in animal tissues and the excretion of urine and feces in the environment is the major source of potential toxicity. Human consumption of meat or milk contaminated with livestock can result in exposure to high levels of IVM exposure. The aim of this study was to reveal the cytotoxic mechanism of IVM in model cell HeLa in?vitro, in order to provide a theoretical basis for the safe and rational use of IVM. Here we observed the γH2AX and 8-oxodG foci to detect the DNA damage in HeLa cells. As expected, we found that IVM can induce oxidative double-stranded damage in HeLa cells, indicating that IVM has potential genotoxicity to human health. In addition, we observed the formation of LC3-B in HeLa cells, the accumulation of Beclin1, the degradation of p62 and the activation of the AMPK/mTOR signal transduction pathway. This suggests that IVM confers cytotoxicity through autophagy mediated by the AMPK/mTOR signaling pathway. We conclude that IVM produces genotoxicity and cytotoxicity by inducing DNA damage and AMPK/mTOR-mediated autophagy, thereby posing a potential risk to human health.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
3-METHYLADENINE 5142-23-4 C6H7N5 392 suppliers $12.00-$1890.00
3-METHYLADENINE 5142-23-4 C6H7N5 392 suppliers $12.00-$1890.00
3-METHYLADENINE 5142-23-4 C6H7N5 392 suppliers $12.00-$1890.00
3-METHYLADENINE 5142-23-4 C6H7N5 392 suppliers $12.00-$1890.00
3H-?Purin-?6-?amine, 3-?methyl- 5142-23-4 C6H7N5 - Inquiry
3H-?Purin-?6-?amine, 3-?methyl- 5142-23-4 C6H7N5 - Inquiry

Similar articles

IF:3.2

PKN2 Promotes Peripheral Nerve Repair by Regulating Autophagy via Activation of the AKT‐mTOR Pathway: An In Vitro Study

Journal of Biochemical and Molecular Toxicology Lin Wang, Yuan‐sheng Huang,etc Published: 22 November 2024
IF:1.6

Maslinic Acid Induces DNA Damage and Impairs DNA Repair in Human Cervical Cancer HeLa Cells.

Anticancer research Kung-Wen Lu, Mei-Due Yang,etc Published: 1 December 2020
陇川县| 浙江省| 化州市| 治县。| 清新县| 呼伦贝尔市| 蒙阴县| 嘉善县| 丰原市| 五大连池市| 连平县| 嘉义市| 固安县| 株洲市| 仁寿县| 北京市| 大同市| 岳阳市| 栾川县| 凤山市| 兴文县| 清徐县| 华宁县| 靖远县| 红安县| 商南县| 茂名市| 襄垣县| 独山县| 苏尼特右旗| 进贤县| 甘肃省| 宁德市| 弥勒县| 昌黎县| 雷州市| 乌苏市| 治县。| 峨眉山市| 昌平区| 许昌市|