一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Biomaterials >>article
Biomaterials

Biomaterials

IF: 12.8
Download PDF

A nanoformulation for immunosuppression reversal and broad-spectrum self-amplifying antitumor ferroptosis-immunotherapy

Published:1 January 2023 DOI: 10.1016/j.biomaterials.2022.121936 PMID: 36502663
Qunfang Yang , Tao Liu , Haiping Zheng , Zechen Zhou , Yan Huang , Honglin Jia , Shixiang Fu , Xuan Zhang , Haigang Zhang , Ya Liu , Xiaohong Chen , Wenjun Shan

Abstract

The efficacy of immunotherapy combined with other therapeutic modalities in the management of cancer has been extensively studied. However, no effective strategy to improve the antitumor effects of immunotherapy at the tumor site has been developed. In this study, we describe a nanoformulation (CP) that integrates ferroptosis-inducing cannabinoid nanoparticles with immunostimulatory Poly(I:C) to enhance antitumor immune responses by activating ferroptosis-immunotherapy pathways. The results indicated that CP nanoformulation effectively induced ferroptosis, cellular immunogenic death, and anti-tumor immune responses which initiate T cell responses leading to the inhibition of established tumors. In addition, CP nanoformulations reversed the tumor immunosuppressive microenvironment and promoted tumor ferroptosis. These results indicated that the self-amplifying nanoformulation may be an effective strategy for broad-spectrum cancer immunotherapy.

Substances (5)

Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
Polyinosinic acid-polycytidylic acid 24939-03-5 C19H27N7O16P2 280 suppliers $22.00-$5053.13
Polyinosinic acid-polycytidylic acid 24939-03-5 C19H27N7O16P2 280 suppliers $22.00-$5053.13
Polyinosinic acid-polycytidylic acid 24939-03-5 C19H27N7O16P2 280 suppliers $22.00-$5053.13
Polyinosinic acid-polycytidylic acid 24939-03-5 C19H27N7O16P2 280 suppliers $22.00-$5053.13

Similar articles

IF:1.8

Toltrazuril effective against a broad spectrum of protozoan parasites.

Parasitology Research H Mehlhorn, G Schmahl,etc Published: 1 January 1988
IF:6.6

Perampanel: Does it have broad-spectrum potential?

Epilepsia Heidrun Potschka, Eugen Trinka,etc Published: 28 June 2018
IF:5.3

Liposomes-mediated enhanced antitumor effect of docetaxel with BRD4-PROTAC as synergist for breast cancer chemotherapy/immunotherapy

International Journal of Pharmaceutics Xixi Chen, Fang Li,etc Published: 19 November 2024
南阳市| 三明市| 虎林市| 精河县| 沁阳市| 资兴市| 巩义市| 北票市| 南溪县| 仁化县| 喀喇沁旗| 喀喇沁旗| 行唐县| 十堰市| 海原县| 安龙县| 托克托县| 西华县| 张北县| 东阿县| 左贡县| 新巴尔虎左旗| 新野县| 桐梓县| 兰州市| 金坛市| 湘潭市| 宣威市| 双桥区| 茂名市| 靖江市| 阜平县| 酒泉市| 徐汇区| 灯塔市| 密云县| 静宁县| 托里县| 防城港市| 祥云县| 延吉市|