一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> International Journal of Impotence Research >>article
International Journal of Impotence Research

International Journal of Impotence Research

IF: 2.79
Download PDF

Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction.

Published:1 June 1996 DOI: PMID: 8858389
M Boolell, M J Allen, S A Ballard, S Gepi-Attee, G J Muirhead, A M Naylor, I H Osterloh, C Gingell

Abstract

Sildenafil (Viagra, UK-92,480) is a novel oral agent under development for the treatment of penile erectile dysfunction. Erection is dependent on nitric oxide and its second messenger, cyclic guanosine monophosphate (cGMP). However, the relative importance of phosphodiesterase (PDE) isozymes is not clear. We have identified both cGMP- and cyclic adenosine monophosphate-specific phosphodiesterases (PDEs) in human corpora cavernosa in vitro. The main PDE activity in this tissue was due to PDE5, with PDE2 and 3 also identified. Sildenafil is a selective inhibitor of PDE5 with a mean IC50 of 0.0039 microM. In human volunteers, we have shown sildenafil to have suitable pharmacokinetic and pharmacodynamic properties (rapid absorption, relatively short half-life, no significant effect on heart rate and blood pressure) for an oral agent to be taken, as required, prior to sexual activity. Moreover, in a clinical study of 12 patients with erectile dysfunction without an established organic cause, we have shown sildenafil to enhance the erectile response (duration and rigidity of erection) to visual sexual stimulation, thus highlighting the important role of PDE5 in human penile erection. Sildenafil holds promise as a new effective oral treatment for penile erectile dysfunction.

Substances (5)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Sildenafil citrate 171599-83-0 C28H38N6O11S 796 suppliers $5.00-$1880.00
Milrinone 78415-72-2 C12H9N3O 541 suppliers $5.00-$1728.00
GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE 7665-99-8 C10H12N5O7P 124 suppliers $43.87-$2053.00
PDE5 2 suppliers Inquiry
PDE2 phosphodiesterase - Inquiry

Similar articles

IF:6.9

Avanafil for the Treatment of Erectile Dysfunction: A Multicenter, Randomized, Double-Blind Study in Men With Diabetes Mellitus

Mayo Clinic proceedings Irwin Goldstein MD , LeRoy A. Jones MD ,etc Published: 1 September 2012
IF:0

Teneligliptin: DPP-4 inhibitor in the treatment of type II Diabetes Mellitus

International Journal of Phytopharmacy K. Danao, M. Shende,etc Published: 30 August 2017
芒康县| 青田县| 福泉市| 绥江县| 金坛市| 永胜县| 岳阳市| 宜兰市| 临沭县| 赤水市| 延长县| 贺兰县| 北川| 全椒县| 大悟县| 廉江市| 乐山市| 策勒县| 西乌珠穆沁旗| 无为县| 遂平县| 灵璧县| 都安| 石屏县| 兰考县| 武胜县| 顺昌县| 涿州市| 修文县| 东阳市| 阿图什市| 若尔盖县| 岳池县| 禄劝| 泰顺县| 馆陶县| 双鸭山市| 岫岩| 河间市| 宿州市| 邵阳市|