一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> iScience >>article
iScience

iScience

IF: 4.6
Download PDF

A network-based computational and experimental framework for repurposing compounds toward the treatment of non-alcoholic fatty liver disease

Published:18 March 2022 DOI: 10.1016/j.isci.2022.103890 PMID: 35252807
Danae Stella Zareifi , Odysseas Chaliotis , Nafsika Chala , Nikos Meimetis , Maria Sofotasiou , Konstantinos Zeakis , Eirini Pantiora , Antonis Vezakis , George K. Matsopoulos , Georgios Fragulidis , Leonidas G. Alexopoulos

Abstract

Non-alcoholic fatty liver disease (NAFLD) is among the most common liver pathologies, however, none approved condition-specific therapy yet exists. The present study introduces a drug repositioning (DR) approach that combines in?vitro steatosis models with a network-based computational platform, constructed upon genomic data from diseased liver biopsies and compound-treated cell lines, to propose effectively repositioned therapeutic compounds. The introduced in silico approach screened 20′000 compounds, while complementary in?vitro and proteomic assays were developed to test the efficacy of the 46 in silico predictions. This approach successfully identified six compounds, including the known anti-steatogenic drugs resveratrol and sirolimus. In short, gallamine triethiotide, diflorasone, fenoterol, and pralidoxime ameliorate steatosis similarly to resveratrol/sirolimus. The implementation holds great potential in reducing screening time in the early drug discovery stages and in delivering promising compounds for in?vivo testing.

Substances (27)

Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
Resveratrol 501-36-0 C14H12O3 1359 suppliers $5.00-$5653.00
Resveratrol 501-36-0 C14H12O3 1359 suppliers $5.00-$5653.00
Resveratrol 501-36-0 C14H12O3 1359 suppliers $5.00-$5653.00
Resveratrol 501-36-0 C14H12O3 1359 suppliers $5.00-$5653.00
Clomiphene Citrate 50-41-9 C32H36ClNO8 455 suppliers $15.00-$930.00
Clomiphene Citrate 50-41-9 C32H36ClNO8 455 suppliers $15.00-$930.00
Clomiphene Citrate 50-41-9 C32H36ClNO8 455 suppliers $15.00-$930.00
Clomiphene Citrate 50-41-9 C32H36ClNO8 455 suppliers $15.00-$930.00
Pralidoxime Chloride 51-15-0 C7H9ClN2O 340 suppliers $5.00-$1050.00
Pralidoxime Chloride 51-15-0 C7H9ClN2O 340 suppliers $5.00-$1050.00

Similar articles

IF:18.5

A Polysaccharide Metal Phenolic Network Nanocomposite for Theranostic Applications in Inflammatory Bowel Disease

Advanced Functional Materials Jianlun Hu, Xiaofeng Wang,etc Published: 22 November 2024
IF:3

Development of artemisinin compounds for cancer treatment.

Investigational New Drugs Henry C Lai, Narendra P Singh,etc Published: 1 February 2013
南川市| 武威市| 铜川市| 普陀区| 彭阳县| 依安县| 南靖县| 交口县| 囊谦县| 诸暨市| 子长县| 诸暨市| 木里| 怀柔区| 广河县| 枣庄市| 磴口县| 巴塘县| 四子王旗| 乳源| 九寨沟县| 柏乡县| 贵南县| 犍为县| 漾濞| 福州市| 东至县| 石泉县| 灌阳县| 特克斯县| 澎湖县| 阜城县| 镇宁| 永济市| 林口县| 蓝田县| 浠水县| 化州市| 鄂托克旗| 师宗县| 永靖县|