一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> International Journal of Cancer >>article
International Journal of Cancer

International Journal of Cancer

IF: 5.7
Download PDF

Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

Published:25 July 2002 DOI: 10.1002/ijc.10570 PMID: 12209581
Vladimir N. Anisimov, Vladimir KH. Khavinson, Mauro Provinciali, Irina N. Alimova, Dmitri A. Baturin, Irina G. Popovich, Mark A. Zabezhinski, Eugeni N. Imyanitov, Romina Mancini, Claudio Franceschi

Abstract

Female FVB/N HER-2/neu transgenic mice from the age of 2 months were subcutaneously injected with saline, the peptide Epitalon? (Ala-Glu-Asp-Gly) or with the peptide Vilon? (Lys-Glu) in a single dose of 1 μg/mouse for 5 consecutive days every month. Epitalon treatment reduced the cumulative number and the maximum size of tumors (p < 0.05). Furthermore, the number of mice bearing 1 mammary tumor was increased, whereas the number of mice bearing 2 or more mammary tumors was reduced in Epitalon-treated in comparison to saline-treated animals (p < 0.05). The size but not the number of lung metastases was reduced in Epitalon-treated compared to saline-treated mice (p < 0.05). The treatment with Vilon produced significant negative effects when compared to the control group, with an increased incidence of mammary cancer development (p < 0.05), a shorter mean latent period of tumors (p < 0.05) and an increased cumulative number of tumors (p < 0.05). A 3.7-fold reduction in the expression of HER-2/neu mRNA was found in mammary tumors from HER-2/neu transgenic mice treated with Epitalon compared to control animals. The expression of mRNA for HER-2/neu was also partially reduced in Vilon-treated mice, but it remained significantly higher in Vilon- than in Epitalon-treated animals (1.9-fold increase). The data demonstrate the inhibitory effect of Epitalon in the development of spontaneous mammary tumors in HER-2/neu mice, suggesting that a downregulation of HER-2/neu gene expression in mammary adenocarcinoma may be responsible, at least in part, for the antitumor effect of the peptide. ? 2002 Wiley-Liss, Inc.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Epitalon 307297-39-8 C14H22N4O9 297 suppliers Inquiry
Epitalon 307297-40-1 C16H26N4O11 17 suppliers $28.00-$1100.00
Vilon Capped 2 suppliers Inquiry

Similar articles

IF:1.8

Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice.

In vivo George Kossoy, Vladimir N Anisimov,etc Published: 1 March 2006
IF:4.9

Progress in the Development of Biosensors Based on Peptide–Copper Coordination Interaction

Biosensors-Basel Gang Liu,?N. Xia,etc Published: 30 September 2022
IF:5.7

Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa.

International journal of molecular medicine G. Kossoy,?J. Zandbank,etc Published: 1 October 2003
车致| 温宿县| 盐津县| 新沂市| 青川县| 扶沟县| 共和县| 若尔盖县| 靖西县| 阿拉善左旗| 绥江县| 嘉善县| 北流市| 临武县| 新邵县| 长寿区| 大悟县| 泸州市| 大姚县| 会理县| 马山县| 获嘉县| 凤台县| 巨鹿县| 景东| 洱源县| 乐昌市| 广平县| 宜君县| 霞浦县| 河曲县| 南雄市| 盈江县| 太仓市| 韩城市| 万荣县| 广饶县| 万盛区| 香格里拉县| 巩义市| 安化县|