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Future medicinal chemistry

Future medicinal chemistry

IF: 3.2
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Triazole-containing hybrids with anti-Mycobacterium tuberculosis potential -?Part I: 1,2,3-Triazole.

Published:1 April 2021 DOI: 10.4155/fmc-2020-0301 PMID: 33619989
Zhenyou Tan, Jun Deng, Qiongxian Ye, Zhenfeng Zhang

Abstract

Tuberculosis regimens currently applied in clinical practice require months of multidrug therapy, which imposes a major challenge of patient compliance and drug resistance development. Moreover, because of?the increasing emergence of hard-to-treat tuberculosis, this disease continues to be a significant threat to the human population. 1,2,3-triazole as a privileged structure has been widely used as an effective template for drug discovery, and 1,2,3-triazole-containing hybrids that can simultaneously act on dual or multiple targets in Mycobacterium tuberculosis?have the potential to circumvent drug resistance, enhance efficacy, reduce side effects and improve pharmacokinetic as well as pharmacodynamic profiles. Thus, 1,2,3-triazole-containing hybrids are useful scaffolds for the development of antitubercular agents. This review aims to highlight recent advances of 1,2,3-triazole-containing hybrids with potential activity against various forms of M. tuberculosis, covering articles published between 2015 and 2020. The structure-activity relationship and the mechanism of action are also discussed to facilitate further rational design of more effective drug candidates.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
1,2,3-1H-Triazole 288-36-8 C2H3N3 561 suppliers $6.00-$1345.11

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