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Biomedical Chromatography

Biomedical Chromatography

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High-resolution mass spectrometry-based methodology for the identification of the metabolites of pterostilbene produced by rat, dog and human hepatocytes

Published:8 April 2021 DOI: 10.1002/bmc.5138 PMID: 33830523
Lingyan Jiang, Renlong Yin, Qiaofei Zheng, Chunyong He, Huichao Chang

Abstract

Pterostilbene, a natural bibenzjyl compound, has been demonstrated to have pleiotropic anticancer effects against a variety of cancer types. The aim of this study was carried out to disclose the metabolic profiles of pterostilbene using rat, dog and human hepatocytes. Metabolites were characterized by ultra-high-performance liquid chromatography/quadrupole Orbitrap mass spectrometry with electrospray ionization interface operating in positive ion mode. The structures of the metabolites were proposed by accurate MS, MS/MS spectra and based on their fragmentation patterns. A total of 12 metabolites, including six new ones, were detected and identified. M10 and M12 were unambiguously identified as pinostilbene and 3′-hydroxy-pterostilbene, respectively, by using reference standards. Our results revealed that pterostilbene was metabolized through the following pathways: (a) hydroxylation to form 3′-hydroxy-pterostilbene (M12), which further undergoes glucuronidation (M9), demethylation (M7) and GSH conjugation through the ortho-quinone intermediate; (b) demethylation to produce desmethyl-pterostilbene (M10), which is further subject to glucuronidation (M4); (c) direct conjugation with glucuronide (M11); and (d) direct sulfation (M8). Among the tested species, no significant species difference was observed. The current study provides valuable information on the metabolism of pterostilbene, which is helpful for us to understand the action of this compound.

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Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
Pinostilbene 42438-89-1 C15H14O3 148 suppliers $25.00-$937.00
Pinostilbene 42438-89-1 C15H14O3 148 suppliers $25.00-$937.00
Pinostilbene 42438-89-1 C15H14O3 148 suppliers $25.00-$937.00
Pinostilbene 42438-89-1 C15H14O3 148 suppliers $25.00-$937.00
Pinostilbene hydrate 42438-89-1 1 suppliers Inquiry
Pinostilbene hydrate 42438-89-1 1 suppliers Inquiry

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