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Talanta

Talanta

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Multidimensional identification of disaccharide isomers based on non-covalent complexes and tandem mass spectrometry

Published:1 November 2022 DOI: 10.1016/j.talanta.2022.123674 PMID: 35717753
Zhan Gao , Yuwen He , Quan He , Wei Wei , Yuanqing Luo , Zihan Ma , Weiwei Chen , Fengjian Chu , Shuheng Zhang , Yaqin Liu , Yuanjiang Pan

Abstract

Glycans are the most abundant organic polymers in nature. They are essential to living organisms and regulate a wide range of biological functions. However, mass spectrometry-based identification of glycan isomers remains challenging due to the complexity of their structures including their complex compositions, linkages, and anomeric configurations. In this study, two novel complex ions, the mononuclear copper-bound dimeric ions [(Cu2+)(A)(L-His)-H]+ and the mononuclear copper-bound quaternary ions [(Cu2+)(A)(L-Ser)3-H]+ (where A denotes a disaccharide, and L-Ser/His denotes l-serine/histidine), were designed for the collision-induced dissociation-based identification and relative quantification of 14 disaccharide isomers. When the unique fragmentation patterns of the above two types of complex ions were mapped into a three-dimensional vector, all the isomers were completely distinguished. Of note, the established method is able to identify mixtures of linkage isomers only using tandem mass spectrometry based on linkage-specific fragment ions of histidine-based complex ions. Finally, the method was successfully applied to the identification and relative quantification of two disaccharide isomers (lactose and sucrose) in dairy beverages. In conclusion, the established method is sensitive to subtle structural differences in disaccharide isomers and has the potential to be used for the differentiation of various glycans.

Substances (28)

Materials
Procduct Name CAS Molecular Formula Supplier Price
D(+)-Trehalose dihydrate 6138-23-4 C12H22O11·2H2O 631 suppliers $6.00-$38440.00
D(+)-Trehalose dihydrate 6138-23-4 C12H22O11·2H2O 631 suppliers $6.00-$38440.00
D(+)-Trehalose dihydrate 6138-23-4 C12H22O11·2H2O 631 suppliers $6.00-$38440.00
D(+)-Trehalose dihydrate 6138-23-4 C12H22O11·2H2O 631 suppliers $6.00-$38440.00
D-(+)-Cellobiose 528-50-7 C12H22O11 521 suppliers $8.00-$2190.00
D-(+)-Cellobiose 528-50-7 C12H22O11 521 suppliers $8.00-$2190.00
D-(+)-Cellobiose 528-50-7 C12H22O11 521 suppliers $8.00-$2190.00
D-(+)-Cellobiose 528-50-7 C12H22O11 521 suppliers $8.00-$2190.00
Maltose 69-79-4 C12H22O11 478 suppliers $5.00-$3029.39
Maltose 69-79-4 C12H22O11 478 suppliers $5.00-$3029.39
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