一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> European Journal of Medicinal Chemistry >>article
European Journal of Medicinal Chemistry

European Journal of Medicinal Chemistry

IF: 6
Download PDF

Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives

Published:1 July 2009 DOI: 10.1016/j.ejmech.2008.07.012 PMID: 18760508
Zahra Rezaei , Soghra Khabnadideh , Keyvan Pakshir , Zahra Hossaini , Fatemeh Amiri , Elham Assadpour

Abstract

This study describes the design, synthesis and evaluation of a novel series of 1,2,4-triazole and benzotriazole derivatives as inhibitors of cytochrome P450 14α-demethylase (14DM). The chemical structures of the new compounds were confirmed by elemental and spectral (1H NMR, 13C NMR, Mass) analyses. Compounds were designed by a generating virtual library of compounds and docking them into the enzyme active site. Furthermore, they were found to have in vitro activity against Microsporum canis, Trichophyton mentagrophyte, Trichophyton rubrum, Epidermophyton floccosum, and Candida albicans comparable to fluconazole and clotrimazole.

Substances (10)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Fluconazole 86386-73-4 C13H12F2N6O 1187 suppliers $5.00-$1504.50
1H-Benzotriazole 95-14-7 C6H5N3 1075 suppliers $6.00-$6515.49
Clotrimazole 23593-75-1 C22H17ClN2 991 suppliers $10.00-$1020.00
1,2,4-Triazole 288-88-0 C2H3N3 954 suppliers $4.00-$2228.00
CANDIDA ALBICANS 39 suppliers Inquiry
Cytochrome P450 4V2 Antibody 19 suppliers Inquiry
Microsporum canis 11 suppliers Inquiry
Epidermophyton floccosum 11 suppliers Inquiry
Trichophyton rubrum 10 suppliers Inquiry
TRICHOPHYTON 1 suppliers Inquiry

Similar articles

IF:3.3

Antioxidant Activity of 1,2,4-Triazole and its Derivatives: A Mini-Review.

Mini reviews in medicinal chemistry Anna Pachuta-Stec,etc Published: 1 January 2022
IF:3.2

Capsaicin derivatives: Synthesis and biological activity

Chemical Biology & Drug Design Shun Liu, Xing Zheng,etc Published: 5 February 2024
IF:11.4

Toxicity of Benzotriazole and Benzotriazole Derivatives to Three Aquatic Species

Water Research David A Pillard , Jeffrey S Cornell ,etc Published: 1 February 2001
乌苏市| 奉新县| 潞西市| 东山县| 平塘县| 抚远县| 德昌县| 阿克苏市| 惠州市| 蛟河市| 水城县| 尼勒克县| 辉县市| 商城县| 安国市| 南投市| 古田县| 静海县| 鞍山市| 苏尼特右旗| 七台河市| 繁峙县| 宝丰县| 丰镇市| 兰坪| 庐江县| 沂南县| 诸暨市| 台山市| 清徐县| 吉木萨尔县| 太和县| 诸暨市| 汪清县| 乌兰察布市| 仙居县| 宁夏| 花莲市| 和林格尔县| 惠州市| 阿拉尔市|