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International immunopharmacology

International immunopharmacology

IF: 4.79
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Pyrogallol, an active compound from the medicinal plant Emblica officinalis, regulates expression of pro-inflammatory genes in bronchial epithelial cells

Published:10 December 2008 DOI: 10.1016/j.intimp.2008.08.001 PMID: 18760383
Elena Nicolis , Ilaria Lampronti , Maria Cristina Dechecchi , Monica Borgatti , Anna Tamanini , Nicoletta Bianchi , Valentino Bezzerri , Irene Mancini , Maria Grazia Giri , Paolo Rizzotti , Roberto Gambari , Giulio Cabrini

Abstract

The most relevant cause of morbidity and mortality in cystic fibrosis (CF) patients is the lung pathology characterized by chronic infection and inflammation sustained mainly by Pseudomonas aeruginosa (P. aeruginosa). Innovative pharmacological approaches to control the excessive inflammatory process in the lung of CF patients are thought to be beneficial to reduce the extensive airway tissue damage. Medicinal plants from the so-called traditional Asian medicine are attracting a growing interest because of their potential efficacy and safety. Due to the presence of different active compounds in each plant extract, understanding the effect of each component is important to pursue selective and reproducible applications. Extracts from Emblica officinalis (EO) were tested in IB3-1 CF bronchial epithelial cells exposed to the P. aeruginosa laboratory strain PAO1. EO strongly inhibited the PAO1-dependent expression of the neutrophil chemokines IL-8, GRO-α, GRO-γ, of the adhesion molecule ICAM-1 and of the pro-inflammatory cytokine IL-6. Pyrogallol, one of the compounds extracted from EO, inhibited the P. aeruginosa-dependent expression of these pro-inflammatory genes similarly to the whole EO extract, whereas a second compound purified from EO, namely 5-hydroxy-isoquinoline, had no effect. These results identify Pyrogallol as an active compound responsible for the anti-inflammatory effect of EO and suggest to extend the investigation in pre-clinical studies in airway animal models in vivo, to test the efficacy and safety of this molecule in CF chronic lung inflammatory disease.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
Pyrogallol 87-66-1 C6H6O3 812 suppliers $6.00-$2300.00
5-Hydroxyisoquinoline 2439-04-5 C9H7NO 167 suppliers $5.00-$1686.30
HUMAN IL-8 378763-92-9 C21H23N3O5S 85 suppliers Inquiry
MOUSE IL-6 71 suppliers $75.00-$1824.00
Cd54 51 suppliers $290.70-$756.00
PSEUDOMONAS AERUGINOSA 17 suppliers Inquiry
GRO-α/ CXCL1 (C-6His), Mouse, Recombinant 9 suppliers Inquiry
Rabbit Anti-Human GRO-γ (CXCL3) 5 suppliers Inquiry
EMBLICA OFFICINALIS 3 suppliers Inquiry

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