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Archives of Pharmacal Research

Archives of Pharmacal Research

IF: 6.9
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Assessment of the anti-angiogenic, anti-inflammatory and antinociceptive properties of ethyl vanillin

Published:2 May 2010 DOI: 10.1007/s12272-010-0217-2 PMID: 20195833
Hyun-Joo Jung, Yun Seon Song, Kyunghoon Kim, Chang-Jin Lim, Eun-Hee Park

Abstract

The present work aimed to assess novel pharmacological properties of ethyl vanillin (EVA) which is used as a flavoring agent for cakes, dessert, confectionary, etc. EVA exhibited an inhibitory activity in the chorioallantoic membrane angiogenesis. Anti-inflammatory activity of EVA was convinced using the two in vivo models, such as vascular permeability and air pouch models in mice. Antinociceptive activity of EVA was assessed using acetic acid-induced writhing model in mice. EVA suppressed production of nitric oxide and induction of inducible nitric oxide synthase in the lipopolysaccharide (LPS)-activated RAW264.7 macrophage cells. However, EVA could not suppress induction of cyclooxygenase-2 in the LPS-activated macrophages. EVA diminished reactive oxygen species level in the LPS-activated macrophages. EVA also suppressed enhanced matrix metalloproteinase-9 gelatinolytic activity in the LPSactivated RAW264.7 macrophage cells. EVA at the used concentrations couldn’t diminish viability of the macrophage cells. Taken together, the anti-angiogenic, anti-inflammatory and anti-nociceptive properties of EVA are based on its suppressive effect on the production of nitric oxide possibly via decreasing the reactive oxygen species level.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
Ethyl vanillin 121-32-4 C9H10O3 885 suppliers $5.00-$1125.00
Ethylene-vinyl acetate copolymer 24937-78-8 (C4H6O2.C2H4)x 307 suppliers $10.00-$503.50
LIPOPOLYSACCHARIDES FROM ESCHERICHIA COL 80 suppliers Inquiry
NITRIC OXIDE 10102-43-9 NO* 63 suppliers $300.00-$9940.00
COX-2 62 suppliers $347.00-$908.00
GELATINASE B 146480-36-6 60 suppliers $282.00-$4180.00
Reactive Oxygen Species 1 suppliers Inquiry

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