一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Drugs >>article
Drugs

Drugs

IF: 13
Download PDF

Linagliptin: in type 2 diabetes mellitus.

Published:26 March 2011 DOI: 10.2165/11207400-000000000-00000 PMID: 21443284
Lesley J Scott

Abstract

Linagliptin, a novel dipeptidyl peptidase-4 (DPP-4) inhibitor, has a favourable pharmacokinetic profile in terms of its predominantly non-renal elimination. It shows highly selective, potent, dose-dependent inhibition of DPP-4, with ≥ 80% inhibition of DPP-4 throughout the 24-hour dosing interval. In two double-blind, multicentre trials (n?>350 evaluable patients/trial) in adult patients with inadequately controlled type 2 diabetes mellitus, oral linagliptin monotherapy (5 or 10?mg once daily) was significantly more effective than placebo in improving glycaemic control and several parameters of pancreatic function, with placebo-corrected adjusted mean changes in glycosylated haemoglobin (HbA(1c)) levels of -0.69% to -0.88% after 12 or 24 weeks. Linagliptin 5 or 10?mg once daily was also significantly more efficacious than voglibose 0.2?mg three times daily in terms of improving glycaemic control in a 26-week, double-blind, multicentre trial (n?>450 evaluable patients). In several similarly designed trials (n?>250 evaluable patients/trial) of 12-24 weeks' duration in adult patients with inadequately controlled type 2 diabetes, oral linagliptin (5?mg once daily) as add-on therapy to metformin, a sulfonylurea drug or metformin plus a sulfonylurea drug, or in combination with pioglitazone, improved glycaemic control significantly more than placebo plus the respective oral antihyperglycaemic therapy, with improvements in adjusted mean HbA(1c) levels considered clinically relevant. Linagliptin, as monotherapy or in combination with other oral antihyperglycaemic drugs, was generally well tolerated in clinical trials, having neutral or minimal effects on bodyweight and generally being associated with a very low incidence of hypoglycaemia.

Substances (4)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Linagliptin 668270-12-0 C25H28N8O2 701 suppliers $5.00-$5450.00
Voglibose 83480-29-9 C10H21NO7 572 suppliers $8.00-$1732.50
Metformin 657-24-9 C4H11N5 222 suppliers $5.00-$2301.00
Pioglitazone 105355-27-9 C19H20N2O3S 38 suppliers Inquiry

Similar articles

IF:13

Dapagliflozin: a review of its use in type 2 diabetes mellitus.

Drugs Greg L Plosker,etc Published: 3 December 2012
IF:4.6

Comparison of glucose lowering effect of metformin and acarbose in type 2 diabetes mellitus: a meta-analysis.

ACS Applied Bio Materials Shuyan Gu,?Jihao Shi,etc Published: 11 May 2015
IF:4.5

Grifola frondosa Polysaccharide Ameliorates Inflammation by Regulating Macrophage Polarization of Liver in Type 2 Diabetes Mellitus Rats

Molecular Nutrition & Food Research Pei Zou, Xueyan Li,etc Published: 26 November 2024
伊通| 上饶市| 依安县| 德州市| 雅安市| 兴仁县| 石嘴山市| 安平县| 阜新市| 健康| 观塘区| 彰化县| 奈曼旗| 罗平县| 客服| 云龙县| 陈巴尔虎旗| 阳东县| 西峡县| 盐边县| 峨山| 五指山市| 公安县| 池州市| 福泉市| 中西区| 望城县| 陇西县| 天柱县| 建昌县| 南木林县| 犍为县| 石家庄市| 尼勒克县| 湟源县| 凤翔县| 安化县| 集安市| 怀安县| 乌兰察布市| 五指山市|