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Drug Design, Development and Therapy

Drug Design, Development and Therapy

IF: 4.7
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8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications.

Published:4 October 2013 DOI: 10.2147/DDDT.S49763 PMID: 24115839
Veda Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul

Abstract

Metal ions play an important role in biological processes and in metal homeostasis. Metal imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 8-Hydroxyquinoline (8HQ) is a small planar molecule with a lipophilic effect and a metal chelating ability. As a result, 8HQ and its derivatives hold medicinal properties such as antineurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities. Herein, diverse bioactivities of 8HQ and newly synthesized 8HQ-based compounds are discussed together with their mechanisms of actions and structure-activity relationships.

Substances (2)

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Procduct Name CAS Molecular Formula Supplier Price
8-Hydroxyquinoline 148-24-3 C9H7NO 1060 suppliers $5.00-$2300.00
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