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Infection and Chemotherapy

IF: 2.79
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Praziquantel treatment in trematode and cestode infections: an update.

Published:1 March 2013 DOI: 10.3947/ic.2013.45.1.32 PMID: 24265948
Jong-Yil Chai

Abstract

Status and emerging issues in the use of praziquantel for treatment of human trematode and cestode infections are briefly reviewed. Since praziquantel was first introduced as a broadspectrum anthelmintic in 1975, innumerable articles describing its successful use in the treatment of the majority of human-infecting trematodes and cestodes have been published. The target trematode and cestode diseases include schistosomiasis, clonorchiasis and opisthorchiasis, paragonimiasis, heterophyidiasis, echinostomiasis, fasciolopsiasis, neodiplostomiasis, gymnophalloidiasis, taeniases, diphyllobothriasis, hymenolepiasis, and cysticercosis. However, Fasciola hepatica and Fasciola gigantica infections are refractory to praziquantel, for which triclabendazole, an alternative drug, is necessary. In addition, larval cestode infections, particularly hydatid disease and sparganosis, are not successfully treated by praziquantel. The precise mechanism of action of praziquantel is still poorly understood. There are also emerging problems with praziquantel treatment, which include the appearance of drug resistance in the treatment of Schistosoma mansoni and possibly Schistosoma japonicum, along with allergic or hypersensitivity reactions against praziquantel treatment. To cope with and overcome these problems, combined use of drugs, i.e., praziquantel and other newly introduced compounds such as triclabendazole, artemisinins, and tribendimidine, is being tried.

Substances (4)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Artemisinin 63968-64-9 C15H22O5 854 suppliers $5.00-$2700.00
Praziquantel 55268-74-1 C19H24N2O2 743 suppliers $5.00-$1504.50
Triclabendazole 68786-66-3 C14H9Cl3N2OS 433 suppliers $5.00-$637.00
tribendimidine 115103-15-6 C28H32N6 52 suppliers Inquiry

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