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Journal of Immunology Research

Journal of Immunology Research

IF: 3.6
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The Effects of 6 Common Antidiabetic Drugs on Anti-PD1 Immune Checkpoint Inhibitor in Tumor Treatment

Published:18 August 2022 DOI: 10.1155/2022/2651790 PMID: 36033393
Ze-Tao Zhan, Lu Liu, Ming-Zhen Cheng, Yi Gao, Wei-Jie Zhou

Abstract

Diabetes and cancer are common diseases and are frequently diagnosed in the same individual. These patients need to take antidiabetic drugs while receiving antitumor drugs therapy. Recently, immunotherapy offers significant advances for cancer treatment. However, it is unclear whether antidiabetic drugs affect immunotherapy. Here, by employing syngeneic mouse colon cancer model and melanoma model, we studied the effects of 6 common antidiabetic drugs on anti-PD1 immune checkpoint inhibitor in tumor treatment, including acarbose, sitagliptin, metformin, glimepiride, pioglitazone, and insulin. We found that acarbose and sitagliptin enhanced the tumor inhibition of anti-PD1, and metformin had no effect on the tumor inhibition of anti-PD1, whereas glimepiride, pioglitazone, and insulin weakened the tumor inhibition of anti-PD1. Our study suggests that cancer patients receiving anti-PD1 antibody therapy need serious consideration when choosing antidiabetic drugs. In particular, acarbose significantly inhibited tumor growth and further enhanced the therapeutic effect of anti-PD1, which can be widely used in tumor therapy. Based on this study, further clinical trials are expected.

Substances (30)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Acarbose 56180-94-0 C25H43NO18 762 suppliers $6.00-$2245.70
Acarbose 56180-94-0 C25H43NO18 762 suppliers $6.00-$2245.70
Acarbose 56180-94-0 C25H43NO18 762 suppliers $6.00-$2245.70
Acarbose 56180-94-0 C25H43NO18 762 suppliers $6.00-$2245.70
Glimepiride 93479-97-1 C24H34N4O5S 711 suppliers $8.00-$1750.00
Glimepiride 93479-97-1 C24H34N4O5S 711 suppliers $8.00-$1750.00
Glimepiride 93479-97-1 C24H34N4O5S 711 suppliers $8.00-$1750.00
Glimepiride 93479-97-1 C24H34N4O5S 711 suppliers $8.00-$1750.00
Sitagliptin 486460-32-6 C16H15F6N5O 580 suppliers $8.00-$1663.75
Sitagliptin 486460-32-6 C16H15F6N5O 580 suppliers $8.00-$1663.75

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