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International Journal of Neuropsychopharmacology

International Journal of Neuropsychopharmacology

IF: 4.5
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D-Cycloserine in Neuropsychiatric Diseases: A Systematic Review.

Published:20 April 2016 DOI: 10.1093/ijnp/pyv102 PMID: 26364274
Sebastian Schade, Walter Paulus

Abstract

D-Cycloserine, known from tuberculosis therapy, has been widely introduced to neuropsychiatric studies, since its central active mechanism as a partial NMDA-agonist has been found. In this review, we evaluate its therapeutic potential in neuropsychological disorders and discuss its pitfalls in terms of dosing and application frequency as well as its safety in low-dose therapy. Therefore, we identified 91 clinical trials by performing a Medline search. We demonstrate in part preliminary but increasing evidence that D-cycloserine may be effective in various psychiatric diseases, including schizophrenia, anxiety disorders, addiction, eating disorders, major depression, and autism as well as in neurological diseases, including dementia, Alzheimer's disease, and spinocerebellar degeneration. D-Cycloserine in low-dose therapy is safe, but there is still a need for new drugs with higher specificity to the different N-methyl-D-aspartate-receptor subunits.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
D-Cycloserine 68-41-7 C3H6N2O2 668 suppliers $5.00-$3346.00
N-Methyl-D-aspartic acid 6384-92-5 C5H9NO4 349 suppliers $8.00-$3330.00

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