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Phytotherapy Research

Phytotherapy Research

IF: 6.1
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Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics.

Published:1 August 2016 DOI: 10.1002/ptr.5631 PMID: 27188216
Xiaoxv Dong,?Jing Fu,?Xingbin Yin,?Sali Cao,?Xuechun Li,?Longfei Lin,?Jian Ni

Abstract

Emodin is a natural anthraquinone derivative that occurs in many widely used Chinese medicinal herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum multiflorum. Emodin has been used as a traditional Chinese medicine for over 2000?years and is still present in various herbal preparations. Emerging evidence indicates that emodin possesses a wide spectrum of pharmacological properties, including anticancer, hepatoprotective, antiinflammatory, antioxidant and antimicrobial activities. However, emodin could also lead to hepatotoxicity, kidney toxicity and reproductive toxicity, particularly in high doses and with long-term use. Pharmacokinetic studies have demonstrated that emodin has poor oral bioavailability in rats because of its extensive glucuronidation. This review aims to comprehensively summarize the pharmacology, toxicity and pharmacokinetics of emodin reported to date with an emphasis on its biological properties and mechanisms of action. Copyright ? 2016 John Wiley & Sons, Ltd.

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Emodin 518-82-1 C15H10O5 714 suppliers $8.00-$1375.00

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