一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> ChemistryOpen >>article
ChemistryOpen

ChemistryOpen

IF: 2.5
Download PDF

Understanding Tetrahydropyranyl as a Protecting Group in Peptide Chemistry

Published:8 March 2017 DOI: 10.1002/open.201600156 PMID: 28413747
Dr. Anamika Sharma, Dr. Iván Ramos-Tomillero, Prof. Ayman El-Faham, Prof. Ernesto Nicolas, Dr. Hortensia Rodriguez, Dr. Beatriz G. de?la?Torre, Prof. Fernando Albericio

Abstract

Tetrahydropyranyl (Thp) is recognized as a useful protecting group for alcohols in organic synthesis. It has several advantages, including low cost, ease of introduction, general stability to most non-acidic reagents, it confers good solubility, and the ease with which it can be removed if the functional group it protects requires manipulation. However, little attention has been paid to Thp in peptide chemistry. Provided here is a concise analysis of the Thp protection of various amino acid functionalities (OH, SH, NH and COOH) and its application to peptide synthesis. Thp is a useful moiety for the side-chain protection of serine, threonine and cysteine and is suitable for the Fmoc/tBu solid-phase peptide synthesis strategy. The immobilized version of 3,4-dihydro-2H-pyran, the so-called Ellman resin, is also discussed as a useful solid support for anchoring the side chains of serine, threonine and tryptophan residues.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
3,4-Dihydro-2H-pyran 110-87-2 C5H8O 644 suppliers $7.62-$1795.00
ELLMAN'S DIHYDROPYRAN RESIN 100-200:mesh,1%DVB 29 suppliers Inquiry
Cholesterol-d7 Tetrahydropyranyl Ether C32H54O2 5 suppliers Inquiry

Similar articles

IF:3.2

Application of the allyloxycarbonyl protecting group for the indole of Trp in solid-phase peptide synthesis*

Chemical Biology & Drug Design THOMAS VORHERR, ARNOLD TRZECIAK,etc Published: 1 December 1996
IF:5.8

Triethyl phosphate (TEP) as a green solvent for solid-phase peptide synthesis (SPPS)

Green Chemistry Letters and Reviews K.P. Nandhini, Nosipho Cele,etc Published: 21 March 2024
IF:0

A Medicinal Chemistry Perspective on Artemisinin and Related Endoperoxides

ChemInform P. O’Neill,?G. Posner,etc Published: 17 August 2004
留坝县| 屏山县| 邯郸县| 大埔区| 张家港市| 宣汉县| 嘉黎县| 合江县| 韶山市| 扬州市| 淳化县| 南川市| 汉沽区| 临漳县| 连江县| 万盛区| 达尔| 富阳市| 临桂县| 湘潭县| 长兴县| 马鞍山市| 罗江县| 漯河市| 丰顺县| 宝应县| 贵溪市| 巴塘县| 韩城市| 略阳县| 邛崃市| 文昌市| 磐安县| 开原市| 东城区| 四会市| 饶阳县| 阿城市| 宁蒗| 宜宾市| 伊川县|