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Oncotarget

Oncotarget

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Baicalein decreases uric acid and prevents hyperuricemic nephropathy in mice

Published:20 June 2017 DOI: 10.18632/oncotarget.16928 PMID: 28445133
Xiaolu Meng, Zhuo Mao, Xin Li, Dandan Zhong, Min Li, Yingli Jia, Jing Wei, Baoxue Yang, Hong Zhou

Abstract

Baicalein, a natural flavonoid, is structurally advantageous for binding to xanthine oxidoreductase. In our study, molecular docking analysis and Surface Plasmon Resonance revealed a direct interaction between baicalein and xanthine oxidoreductase. Moreover, 50 mg/kg/d baicalein treatment significantly suppressed the viability of xanthine oxidoreductase in hyperuricemia mouse model. The data showed that baicalein remarkably prevented renal dysfunction, ameliorated kidney fibrosis, alleviated epithelial-mesenchymal transition and oxidative stress in hyperuricemia mice. Thus, we concluded that baicalein executed a kidney-protection action in hyperuricemia and therefore may be used as a therapeutic alternative for hyperuricemic nephropathy.

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Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
Baicalein 491-67-8 C15H10O5 576 suppliers $5.00-$1074.00
Baicalein 491-67-8 C15H10O5 576 suppliers $5.00-$1074.00
Baicalein 491-67-8 C15H10O5 576 suppliers $5.00-$1074.00
Baicalein 491-67-8 C15H10O5 576 suppliers $5.00-$1074.00
Baicalein 491-67-8 - Inquiry
Baicalein 491-67-8 - Inquiry

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