一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Research in Pharmaceutical Sciences >>article

Research in Pharmaceutical Sciences

IF: 2.1
Download PDF

Effect of acute and long term potassium bromide administration on spatial working memory in rat.

Published:1 April 2017 DOI: 10.4103/1735-5362.202454 PMID: 28515768
Faezeh Safdari, Mohammad Rabbani, Ali Hosseini-Sharifabad

Abstract

Potassium bromide (KBr), an old antiepileptic agent, is illegally used in pharmaceutical or food industries to improve the product appearance. KBr has been proven to influence several pathways which are important in memory formation. Therefore, the present study aimed to evaluate the effect of KBr on spatial working memory using object recognition task (ORT). Rats received a single dose of KBr (50, 100 or 150 mg/kg), per oral, in acute treatment. KBr long term effects were also studied in animals receiving 50 mg/kg/day of KBr for 28 consecutive days. At the end of treatments, animals underwent two trials of ORT, five min each. In the first trial (T1), animals encountered with two identical objects for exploration. After 1 h, the animals were exposed to a familiar and an unfamiliar object (T2). The exploration times for discrimination (D) and recognition (R) as well as the frequency of exploration for any objects were determined. Acute administration of 150 mg/kg of KBr significantly decreased the discrimination and recognition indices (RI and DI) (P < 0.01) compared to the control. However, lower doses failed to influence the animals' performance in the test. In addition, long term administration of KBr remarkably diminished the DI and RI and the frequency of exploration (P < 0.05). The results of this study indicate that acute doses of KBr as high as 150 mg/kg are required to hamper memory function in ORT. However, cognitive impairment occured with lower doses of KBr when the duration of treatment is extended.

Substances (1)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Potassium bromide 7758-02-3 BrK 771 suppliers $14.00-$1660.00

Similar articles

IF:8.1

Adverse cardiovascular effects of long-term exposure to diethyl phthalate in the rat aorta

Chemosphere Melissa Mariana , Margarida Lorigo ,etc Published: 1 November 2023
IF:0

Long-term toxicity of sodium cyclamate in mice

Food and cosmetics toxicology P.G Brantom , I.F Gaunt ,etc Published: 1 October 1973
北碚区| 乌拉特后旗| 福安市| 云林县| 昌江| 邛崃市| 海南省| 镇原县| 鄱阳县| 宾川县| 富裕县| 屯昌县| 斗六市| 呈贡县| 威海市| 安龙县| 手机| 萍乡市| 广宗县| 平顶山市| 小金县| 垦利县| 二连浩特市| 腾冲县| 平遥县| 卢氏县| 道孚县| 镇沅| 会宁县| 翼城县| 常德市| 平泉县| 买车| 宜黄县| 晋州市| 平凉市| 余江县| 柯坪县| 朝阳市| 教育| 冀州市|