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Scientific Reports

Scientific Reports

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Halogenated Chrysins Inhibit Dengue and Zika Virus Infectivity

Published:20 October 2017 DOI: 10.1038/s41598-017-14121-5 PMID: 29057920
Aphinya Suroengrit, Wanchalerm Yuttithamnon, Pimsiri Srivarangkul, Saran Pankaew, Krongkan Kingkaew, Warinthorn Chavasiri, Siwaporn Boonyasuppayakorn

Abstract

Dengue virus infection is a global threat for which no specific treatment has not been established. Previous reports suggested chrysin and flavanone derivatives were potential flaviviral inhibitors. Here, we reported two halogenated chrysins, abbreviated FV13 and FV14, were highly potent against DENV1-4 and ZIKV infectivities with the FV13 EC50 values of 2.30?±?1.04, 1.47?±?0.86, 2.32?±?1.46, 1.78?±?0.72 and 1.65?±?0.86?μM; and FV14 EC50 values of 2.30?±?0.92, 2.19?±?0.31, 1.02?±?0.31, 1.29?±?0.60 and 1.39?±?0.11?μM, respectively. The CC50s to LLC/MK2 of FV13 and FV14 were 44.28?±?2.90?μM, 42.51?±?2.53?μM, respectively. Mechanism of drug action studies suggested multiple targets but maximal efficiency was achieved with early post infection treatment. This is the first report showing a high potency of halogenated chrysins for development as a broad-spectrum anti-flaviviral drug.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Ribavirin 36791-04-5 C8H12N4O5 743 suppliers $5.00-$1600.00
Ribavirin 36791-04-5 C8H12N4O5 743 suppliers $5.00-$1600.00
Ribavirin 36791-04-5 C8H12N4O5 743 suppliers $5.00-$1600.00
Ribavirin 36791-04-5 C8H12N4O5 743 suppliers $5.00-$1600.00

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