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PLoS ONE

PLoS ONE

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Static magnetic field enhances the anticancer efficacy of capsaicin on HepG2 cells via capsaicin receptor TRPV1

Published:16 January 2018 DOI: 10.1371/journal.pone.0191078 PMID: 29338036
Wei-Ting Chen, Guan-Bo Lin, Shu-Hui Lin, Chueh-Hsuan Lu, Chih-Hsiung Hsieh, Bo-Lun Ma, Chih-Yu Chao

Abstract

Static magnetic field (SMF) has shown some possibilities for cancer therapies. In particular, the combinational effect between SMF and anti-cancer drugs has drawn scientists' attentions in recent years. However, the underlying mechanism for the drug-specific synergistic effect is far from being understood. Besides, the drugs used are all conventional chemotherapy drugs, which may cause unpleasant side effects. In this study, our results demonstrate for the first time that SMF could enhance the anti-cancer effect of natural compound, capsaicin, on HepG2 cancer cells through the mitochondria-dependent apoptosis pathway. We found that the synergistic effect could be due to that SMF increased the binding efficiency of capsaicin for the TRPV1 channel. These findings may provide a support to develop an application of SMF for cancer therapy. The present study offers the first trial in combining SMF with natural compound on anti-cancer treatment, which provides additional insight into the interaction between SMF and anti-cancer drugs and opens the door for the development of new strategies in fighting cancer with minimum cytotoxicity and side effects.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
SB-705498 501951-42-4 C17H16BrF3N4O 133 suppliers $10.00-$3284.00
SB-705498 501951-42-4 C17H16BrF3N4O 133 suppliers $10.00-$3284.00
SB-705498 501951-42-4 C17H16BrF3N4O 133 suppliers $10.00-$3284.00
SB-705498 501951-42-4 C17H16BrF3N4O 133 suppliers $10.00-$3284.00

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