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Applied Microbiology and Biotechnology

Applied Microbiology and Biotechnology

IF: 3.9
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4-Hydroxybenzoic acid—a versatile platform intermediate for value-added compounds

Published:7 March 2018 DOI: 10.1007/s00253-018-8815-x PMID: 29516141
Songwei Wang, Muhammad Bilal, Hongbo Hu, Wei Wang, Xuehong Zhang

Abstract

4-Hydroxybenzoic acid (4-HBA) has recently emerged as a promising intermediate for several value-added bioproducts with potential biotechnological applications in food, cosmetics, pharmacy, fungicides, etc. Over the past years, a variety of biosynthetic techniques have been developed for producing the 4-HBA and 4-HBA-based products. At this juncture, synthetic biology and metabolic engineering approaches enabled the biosynthesis of 4-HBA to address the increasing demand for high-value bioproducts. This review summarizes the biosynthesis of a variety of industrially pertinent compounds such as resveratrol, muconic acid, gastrodin, xiamenmycin, and vanillyl alcohol using 4-HBA as the starting feedstock. Moreover, potential research activities with a close-up look at the future perspectives to produce new compounds using 4-HBA have also been discussed.

Substances (5)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Resveratrol 501-36-0 C14H12O3 1359 suppliers $5.00-$5653.00
4-Hydroxybenzoic acid 99-96-7 C7H6O3 997 suppliers $5.00-$2460.00
Gastrodin 62499-27-8 C13H18O7 454 suppliers $5.00-$2910.60
Vanillyl alcohol 498-00-0 C8H10O3 438 suppliers $10.00-$4341.65
trans,trans-Muconic acid 3588-17-8 C6H6O4 192 suppliers $12.00-$1320.00

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