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Epilepsy and Behavior Case Reports

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Lacosamide may improve cognition in patients with focal epilepsy: EpiTrack to compare cognitive side effects of lacosamide and carbamazepine

Published:1 January 2018 DOI: 10.1016/j.ebcr.2018.02.004 PMID: 29977793
Claudio Liguori , Francesca Izzi , Natalia Manfredi , Nicola Biagio Mercuri , Fabio Placidi

Abstract

Carbamazepine (CBZ) is a first generation anti-seizure drug, considered as first choice therapy in focal epilepsy but associated with cognitive side effects. Lacosamide (LCM) is a third-generation anti-seizure drug approved for treating focal epilepsy. This case series documented the comparable efficacy of LCM and CBZ as first add on treatments in patients affected by uncontrolled focal seizures. LCM showed an increase in EpiTrack scores, which measure cognitive abilities, at follow-up compared to CBZ. This preliminary data may represent the basis for future prospective studies aimed at comparing the long-term cognitive side effects of LCM and CBZ.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
Carbamazepine 298-46-4 C15H12N2O 791 suppliers $7.00-$2055.90
Lacosamide 175481-36-4 C13H18N2O3 535 suppliers $49.00-$800.00

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