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Journal of Molecular Cell Biology

Journal of Molecular Cell Biology

IF: 5.9
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IFN-stimulated P2Y 13 protects mice from viral infection by suppressing the cAMP/EPAC1 signaling pathway

Published:1 May 2019 DOI: 10.1093/jmcb/mjy045 PMID: 30137373
Chengfei Zhang, Yan Yan, Hongwang He, Li Wang, Na Zhang, Jie Zhang, Hongjun Huang, Nannan Wu, Hua Ren, Min Qian, Mingyao Liu, Bing Du

Abstract

Among the most important sensors of extracellular danger signals, purinergic receptors have been demonstrated to play crucial roles in host defense against infection. However, the function of P2 receptors in viral infection has been little explored. Here we demonstrated that P2Y13 and its ligand ADP play an important role in protecting hosts from viral infections. First, we demonstrate that P2Y13, as a typical interferon-stimulated gene, is induced together with extracellular ADP during viral infection. Most importantly, extracellular ADP restricts the replication of different kinds of viruses, including vesicular stomatitis virus, Newcastle disease virus, herpes simplex virus 1, and murine leukemia virus. This kind of protection is dependent on P2Y13 but not P2Y1 or P2Y12, which are also considered as receptors for ADP. Furthermore, cyclic adenosine monophosphate and EPAC1 are downregulated by extracellular ADP through the P2Y13-coupled Gi alpha subunit. Accordingly, inhibition or deletion of EPAC1 significantly eliminates ADP/P2Y13-mediated antiviral activities. Taken together, our results show that P2Y13 and ADP play pivotal roles in the clearance of invaded virus and have the potential as antiviral targets.

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Materials
Procduct Name CAS Molecular Formula Supplier Price
Ruxolitinib 941678-49-5 C17H18N6 461 suppliers $10.00-$2757.40
Ruxolitinib 941678-49-5 C17H18N6 461 suppliers $10.00-$2757.40
Ruxolitinib 941678-49-5 C17H18N6 461 suppliers $10.00-$2757.40
Ruxolitinib 941678-49-5 C17H18N6 461 suppliers $10.00-$2757.40

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