一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> ACS Catalysis >>article
ACS Catalysis

ACS Catalysis

IF: 11.3
Download PDF

Requirement for YAP1 signaling in myxoid liposarcoma

Published:1 May 2019 DOI: 10.15252/emmm.201809889 PMID: 30898787
Marcel Trautmann, Ya-Yun Cheng, Patrizia Jensen, Ninel Azoitei, Ines Brunner, Jennifer Hüllein, Mikolaj Slabicki, Ilka Isfort, Magdalene Cyra, Ruth Berthold, Eva Wardelmann, Sebastian Huss, Bianca Altvater, Claudia Rossig, Susanne Hafner, Thomas Simmet, Anders St?hlberg, Pierre ?man, Thorsten Zenz, Undine Lange, Thomas Kindler, Claudia Scholl, Wolfgang Hartmann, Stefan Fr?hling

Abstract

Myxoid liposarcomas (MLS), malignant tumors of adipocyte origin, are driven by the FUS-DDIT3 fusion gene encoding an aberrant transcription factor. The mechanisms whereby FUS-DDIT3 mediates sarcomagenesis are incompletely understood, and strategies to selectively target MLS cells remain elusive. Here we show, using an unbiased functional genomic approach, that FUS-DDIT3-expressing mesenchymal stem cells and MLS cell lines are dependent on YAP1, a transcriptional co-activator and central effector of the Hippo pathway involved in tissue growth and tumorigenesis, and that increased YAP1 activity is a hallmark of human MLS Mechanistically, FUS-DDIT3 promotes YAP1 expression, nuclear localization, and transcriptional activity and physically associates with YAP1 in the nucleus of MLS cells. Pharmacologic inhibition of YAP1 activity impairs the growth of MLS cells in?vitro and in?vivo These findings identify overactive YAP1 signaling as unifying feature of MLS development that could represent a novel target for therapeutic intervention.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Verteporfin 129497-78-5 2C41H42N4O8 251 suppliers $24.00-$4655.00
Verteporfin 129497-78-5 2C41H42N4O8 251 suppliers $24.00-$4655.00
Verteporfin 129497-78-5 2C41H42N4O8 251 suppliers $24.00-$4655.00
Verteporfin 129497-78-5 2C41H42N4O8 251 suppliers $24.00-$4655.00

Similar articles

IF:3.2

Sodium thiosulfate: A donor or carrier signaling molecule for hydrogen sulfide?

Nitric oxide : biology and chemistry Si-Miao Tang , Guo-Zhong Lu ,etc Published: 17 June 2024
IF:2.5

Abscisic acid signaling in seeds and seedlings.

Journal of Clinical Psychology Ruth R Finkelstein,?Srinivas S L Gampala,etc Published: 1 January 2002
IF:5.4

Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer's Disease.

ACS Applied Energy Materials María Jesús Friedli, Nibaldo C Inestrosa,etc Published: 29 October 2021
鲜城| 武平县| 晋中市| 文化| 鹰潭市| 高青县| 横峰县| 舟山市| 商洛市| 宜章县| 扬州市| 久治县| 金沙县| 玉环县| 新和县| 兴安盟| 淮阳县| 商洛市| 泰宁县| 崇州市| 琼中| 凌源市| 辽源市| 南陵县| 武威市| 香港 | 肇州县| 保山市| 区。| 兰考县| 博罗县| 内黄县| 瑞金市| 德兴市| 麻阳| 麻栗坡县| 酒泉市| 台前县| 延长县| 全州县| 伊通|