一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of psychiatric research >>article
Journal of psychiatric research

Journal of psychiatric research

IF: 3.2
Download PDF

Interactome Analyses implicated CAMK2A in the genetic predisposition and pharmacological mechanism of Bipolar Disorder

Published:1 August 2019 DOI: 10.1016/j.jpsychires.2019.05.024 PMID: 31150948
Huijuan Li , Dong-Sheng Zhou , Hong Chang , Lu Wang , Weipeng Liu , Shao-Xing Dai , Chen Zhang , Jun Cai , Weiqing Liu , Xingxing Li , Weixing Fan , Wei Tang , Wenxin Tang , Fang Liu , Yuanfang He , Yan Bai , Zhonghua Hu , Xiao Xiao , Lei Gao , Ming Li

Abstract

Bipolar disorder (BPD) is a severe mental illness characterized by fluctuations in mood states, behaviors and energy levels. Growing evidence suggests that genes associated with specific illnesses tend to interact together and encode a tight protein-protein interaction (PPI) network, providing valuable information for understanding their pathogenesis. To gain insights into the genetic and physiological foundation of BPD, we conduct the physical PPI analysis of 184 BPD risk genes distilled from genome-wide association studies and exome sequencing studies. We have identified several hub genes (CAMK2A, HSP90AA1 and PLCG1) among those risk genes, and observed significant enrichment of the BPD risk genes in certain pathways such as calcium signaling, oxytocin signaling and circadian entrainment. Furthermore, while none of the 184 genetic risk genes are “well established” BPD drug targets, our PPI analysis showed that αCaMKII (encoded by CAMK2A) had direct physical PPIs with targets (HRH1, SCN5A and CACNA1E) of clinically used anti-manic BPD drugs, such as carbamazepine. We thus speculated that αCaMKII might be involved in the cellular pharmacological actions of those drugs. Using cultured rat primary cortical neurons, we found that carbamazepine treatment induced phosphorylation of αCaMKII in dose-dependent manners. Intriguingly, previous study showed that CAMK2A heterozygous knockout (CAMK2A+/-) mice exhibited infradian oscillation of locomotor activities that can be rescued by carbamazepine. Our data, in combination with previous studies, provide convergent evidence for the involvement of CAMK2A in the risk of BPD.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Carbamazepine 298-46-4 C15H12N2O 804 suppliers $7.00-$2055.90
Carbamazepine 298-46-4 C15H12N2O 804 suppliers $7.00-$2055.90
Carbamazepine 298-46-4 C15H12N2O 804 suppliers $7.00-$2055.90
Carbamazepine 298-46-4 C15H12N2O 804 suppliers $7.00-$2055.90
Carbamazepine 298-46-4 - Inquiry
Carbamazepine 298-46-4 - Inquiry

Similar articles

IF:0

Liraglutide results in significant weight loss in patients with bipolar disorder

The Brown University Psychopharmacology Update Published: 4 June 2024
IF:5.4

Pharmacological mechanism of roflumilast in the treatment of asthma-COPD overlap.

ACS Applied Energy Materials Xiaoli Zhang, Yuqing Chen,etc Published: 1 August 2018
IF:3.2

Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action

Phytochemistry Renuka Mani, Vijayakumar Natesan,etc Published: 1 January 2018
兴义市| 福建省| 长岛县| 庐江县| 巴东县| 庄浪县| SHOW| 宜都市| 格尔木市| 宣汉县| 成安县| 嘉义县| 咸阳市| 成安县| 襄汾县| 荔波县| 潮州市| 阿拉善右旗| 融水| 林芝县| 陈巴尔虎旗| 礼泉县| 哈密市| 长宁县| 玉树县| 谷城县| 临沭县| 金沙县| 东港市| 乌兰浩特市| 罗城| 乌拉特前旗| 泉州市| 进贤县| 张家港市| 三门县| 浏阳市| 蚌埠市| 古交市| 望江县| 绥中县|