一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of Controlled Release >>article
Journal of Controlled Release

Journal of Controlled Release

IF: 10.5
Download PDF

Self-assembling mertansine prodrug improves tolerability and efficacy of chemotherapy against metastatic triple-negative breast cancer

Published:1 February 2020 DOI: 10.1016/j.jconrel.2019.12.027 PMID: 31857101
Wei Ran , Xiaoyu Liu , Lu Chang , Ying Cai , Chao Zheng , Jia Liu , Yaping Li , Pengcheng Zhang

Abstract

Metastatic triple-negative breast cancer is one of the most devastating cancer types. Systemic chemotherapy is necessary, but its clinical performance is largely limited by severe side effects. Herein, we report a mertansine prodrug, which could self-assemble into spherical nanoparticles in water and readily convert into active mertansine at the presence of glutathione. The self-assembling mertansine prodrugs (SAMPDs) entered cancer cells via a caveolae-mediated pathway and exhibited potent cytotoxicity. The self-delivering SAMPDs did not cause hemolysis, and more importantly increased maximum tolerated dose (MTD) of mertansine by 8 folds via reducing free mertansine exposure in most of the major organs. SAMPDs improved intratumoral drug exposure and showed dose-dependent antitumor activity. When dosed at MTD, SAMPDs inhibited primary tumor growth and pulmonary metastasis by 80% and 95%, while mertansine dosed at MTD only reduced primary tumor growth and metastasis by <50% and 60%, respectively. Our results reveal the mechanism of in vivo biotransformation of self-assembling prodrug and highlight the unique advantages of self-assembling prodrug strategy in improving the efficacy and safety of chemotherapy.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Glutathione 70-18-8 C10H17N3O6S 1413 suppliers $6.00-$3580.00
Mertansine 139504-50-0 C35H48ClN3O10S 258 suppliers $20.00-$2841.00

Similar articles

IF:10

Hybrid Cell Membrane‐Coated Nanoparticles for Synergizing Sonodynamic Therapy and Immunotherapy against Triple‐Negative Breast Cancer

Advanced Healthcare Materials Jiali Gong, Danling Cheng,etc Published: 21 November 2024
IF:4.6

Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer.

iScience Xu Yang,?Li Deng,etc Published: 16 October 2023
IF:7.1

Cold atmospheric plasma restores skewed macrophage polarization in triple negative breast cancers via enhancing KAT6A acetylation

Free Radical Biology and Medicine Kaiyuan Zhu, Qing lv,etc Published: 23 November 2024
泽库县| 西城区| 长泰县| 敦化市| 务川| 奎屯市| 缙云县| 务川| 八宿县| 饶平县| 开化县| 曲周县| 石渠县| 夏邑县| 万荣县| 安陆市| 奈曼旗| 宁德市| 石河子市| 攀枝花市| 光泽县| 阆中市| 黑水县| 镇宁| 阿荣旗| 外汇| 武乡县| 锡林浩特市| 阳江市| 津市市| 永定县| 当涂县| 拜泉县| 临泽县| 沧州市| 南皮县| 榕江县| 临武县| 哈尔滨市| 东城区| 裕民县|