一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Molecular medicine reports >>article
Molecular medicine reports

Molecular medicine reports

IF: 3.4
Download PDF

Isoferulic acid inhibits human leukemia cell growth through induction of G2/M-phase arrest and inhibition of Akt/mTOR signaling

Published:1 March 2020 DOI: 10.3892/mmr.2020.10926 PMID: 31922221
Zhiguo Long, Guangjia Feng, Na Zhao, Lei Wu, Hongbo Zhu

Abstract

Hematologic malignancy is a serious disease that develops quickly and aggressively, severely threatening human health owing to its high mortality. The current study aimed to evaluate the antitumor effects of isoferulic acid (IFA) on leukemia cells and investigate the possible molecular mechanisms. Hematologic cancer cell lines (Raji, K562 and Jurkat) were treated with IFA in a dose?dependent manner and proliferation was measured by a cell proliferation assay. Cell cycle arrest was detected via flow cytometry using propidium iodide (PI) staining. Cell apoptosis and apoptosis?associated signal pathways were analyzed via Annexin V/PI staining and western blot assays, respectively. IFA inhibited cell viability, induced cell apoptosis and triggered cell cycle arrest in G2/M phase in Raji, K562, and Jurkat cells in a dose?dependent manner. In response to IFA treatment, the levels of cleaved poly(ADP?ribose) polymerase and cleaved caspase?3 were increased in Jurkat and K562 cells, which was associated with increased phosphorylation of Cdc2 and reduction of Cyclin B1 levels. IFA remarkably attenuated the phosphorylation of mTOR and Akt in Jurkat cells. Collectively, the present data suggested that IFA had therapeutic effects on Jurkat, K562, and Raji cells, indicating it as a promising candidate for the treatment of hematologic malignancy.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
3-Hydroxy-4-methoxycinnamic acid 537-73-5 C10H10O4 376 suppliers $5.00-$2905.00
3-Hydroxy-4-methoxycinnamic acid 537-73-5 C10H10O4 376 suppliers $5.00-$2905.00
3-Hydroxy-4-methoxycinnamic acid 537-73-5 C10H10O4 376 suppliers $5.00-$2905.00
3-Hydroxy-4-methoxycinnamic acid 537-73-5 C10H10O4 376 suppliers $5.00-$2905.00
麦盖提县| 兴文县| 晋中市| 临朐县| 崇礼县| 苗栗市| 万宁市| 开江县| 巴彦县| 高要市| 武鸣县| 舟曲县| 彝良县| 太仆寺旗| 合肥市| 湘阴县| 凯里市| 洛阳市| 中宁县| 阳信县| 南和县| 黄陵县| 德安县| 莱阳市| 大竹县| 红桥区| 迭部县| 莱州市| 镇坪县| 黎城县| 荔浦县| 夏河县| 云和县| 衢州市| 凌海市| 凌云县| 巫溪县| 定州市| 延津县| 庄河市| 罗源县|