一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> ACS Chemical Neuroscience >>article
ACS Chemical Neuroscience

ACS Chemical Neuroscience

IF: 4.1
Download PDF

Baloxavir Marboxil: A Review in Acute Uncomplicated Influenza.

Published:1 July 2020 DOI: 10.1007/s40265-020-01350-8 PMID: 32601915
Matt Shirley

Abstract

Baloxavir marboxil (Xofluza?; hereafter referred to as baloxavir), the prodrug of baloxavir acid, is a first-in-class, small molecule inhibitor of the polymerase acidic (PA) protein subunit of the influenza virus polymerase complex. Baloxavir (after conversion to baloxavir acid) acts to block influenza virus replication by inhibiting the cap-dependent endonuclease activity of the PA protein. Taken orally as a single dose, baloxavir is approved in the USA for the treatment of acute uncomplicated influenza in patients ≥?12?years of age who have been symptomatic for ≤?48?h. Data from randomized, double-blind, placebo- and oseltamivir-controlled phase?III trials have shown that baloxavir is efficacious in improving influenza symptoms both in otherwise healthy adolescents and adults and in those at high risk of influenza complications, displaying similar efficacy to that of oseltamivir. Furthermore, there is evidence that baloxavir can reduce influenza viral load more rapidly than oseltamivir. Baloxavir has activity against influenza?A and B viruses (including strains resistant to neuraminidase inhibitors) and is well tolerated. Evidence of the emergence and likely human-to-human transmission of variant viruses with reduced susceptibility to baloxavir highlights the importance of monitoring and surveillance for changes in influenza virus drug susceptibility patterns. However, currently available evidence suggests that baloxavir, with the benefits of a single oral dose regimen, provides a useful alternative to neuraminidase inhibitors for the treatment of acute uncomplicated influenza in adolescents and adults.

Substances (4)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Baloxavir marboxil 1985606-14-1 C27H23F2N3O7S 369 suppliers Inquiry
Baloxavir 1985605-59-1 C24H19F2N3O4S 235 suppliers Inquiry
Oseltamivir 196618-13-0 C16H28N2O4 233 suppliers Inquiry
Baloxavir acid - Inquiry

Similar articles

IF:5.4

Baloxavir Marboxil: An Original New Drug against Influenza.

ACS Applied Energy Materials Fran?ois Dufrasne,etc Published: 24 December 2021
IF:2.9

Safety, Tolerability, and Pharmacokinetics of the Novel Anti-influenza Agent Baloxavir Marboxil in Healthy Adults: Phase I Study Findings.

Clinical Drug Investigation Hiroki Koshimichi, Toru Ishibashi,etc Published: 1 December 2018
IF:1.5

Acute Disulfiram Poisoning in a Child: A Case Report and Review of Literature.

Indian Journal of Critical Care Medicine Kapil Bhalla, Kundan Mittal,etc Published: 1 March 2020
睢宁县| 铜梁县| 西城区| 册亨县| 宿迁市| 水富县| 株洲县| 新源县| 永昌县| 甘德县| 景宁| 玉溪市| 呼伦贝尔市| 宜昌市| 永州市| 浦城县| 行唐县| 赤水市| 达拉特旗| 绩溪县| 永川市| 监利县| 孟连| 安图县| 正安县| 紫阳县| 四会市| 温宿县| 汝州市| 绵阳市| 新建县| 云南省| 沙田区| 栾城县| 交城县| 五寨县| 北辰区| 汉源县| 罗定市| 扶绥县| 含山县|