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Nutrients

Nutrients

IF: 4.8
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Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice

Published:29 June 2020 DOI: 10.3390/nu12071927 PMID: 32610585
Ki-Shuk Shim, Youn-Hwan Hwang, Seon-A Jang, Taesoo Kim, Hyunil Ha

Abstract

In Asia, extracts of Lysimachia christinae have been used for liver or urinogenital system-related diseases in traditional medicine. In this study, we investigated the effects of the water extract of L. christinae (WELC) on receptor activator of nuclear factor-kappa Β ligand (RANKL)-induced osteoclastic differentiation of bone marrow macrophages, and on osteoporosis and obesity in ovariectomy mice. RANK signaling pathways related to osteoclast differentiation were examined by real-time polymerase chain reaction (PCR) and western blot analysis. Additionally, we performed micro-computed tomography to assess trabecular bone loss, histological analysis for fat accumulation in adipose, liver, and bone tissues, and phytochemical profiling for WELC characterization. WELC significantly inhibited osteoclast differentiation by downregulating RANKL-induced mitogen-activated protein kinase (MAPK)/c-Fos/nuclear factor of activated T-cells (NFAT) signaling in osteoclast precursors and ovariectomy-induced trabecular loss by suppressing osteolcastic bone resorption. WELC markedly decreased ovariectomy-induced body weight gain and fat accumulation in adipose, liver, and bone tissues. Furthermore, ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) identified 16 phytochemicals in WELC when compared with the mass fragmentation of standard chemicals. Collectively, these results suggest that WELC might possess beneficial effects on postmenopausal osteoporosis by inhibiting osteoclast differentiation and obesity by suppressing fat accumulation.

Substances (86)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Betaine 107-43-7 C5H11NO2 1012 suppliers $4.00-$4341.04
Betaine 107-43-7 C5H11NO2 1012 suppliers $4.00-$4341.04
Betaine 107-43-7 C5H11NO2 1012 suppliers $4.00-$4341.04
Betaine 107-43-7 C5H11NO2 1012 suppliers $4.00-$4341.04
Chlorogenic acid 327-97-9 C16H18O9 885 suppliers $5.00-$1295.00
Chlorogenic acid 327-97-9 C16H18O9 885 suppliers $5.00-$1295.00
Chlorogenic acid 327-97-9 C16H18O9 885 suppliers $5.00-$1295.00
Chlorogenic acid 327-97-9 C16H18O9 885 suppliers $5.00-$1295.00
Quercetin 117-39-5 C15H10O7 802 suppliers $5.00-$3876.00
Quercetin 117-39-5 C15H10O7 802 suppliers $5.00-$3876.00

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