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ACS Applied Materials & Interfaces

ACS Applied Materials & Interfaces

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Combinatory Treatment with miR-7-5p and Drug-Loaded Cubosomes Effectively Impairs Cancer Cells

Published:17 July 2020 DOI: 10.3390/ijms21145039 PMID: 32708846
Ewa Gajda,?Marlena Godlewska,?Zenon Mariak,?Ewa Nazaruk,?Damian Gawel

Abstract

Background: Multidrug resistance (MDR) is an emerging problem in the treatment of cancer. Therefore, there is a necessity for novel strategies that would sensitize tumor cells to the administered chemotherapeutics. One of the innovative approaches in fighting drug-resistant tumors is the treatment of cancer with microRNA (miRNA), or the use of cubosomes (lipid nanoparticles) loaded with drugs. Here, we present a study on a novel approach, which combines both tools.

Methods: Cubosomes loaded with miR-7-5p and chemotherapeutics were developed. The effects of drug- and miRNA-loaded vehicles on glioma- (A172, T98G), papillary thyroid- (TPC-1) and cervical carcinoma-derived (HeLa) cells were analyzed using molecular biology techniques, including quantitative real-time PCR, MTS-based cell proliferation test, flow cytometry and spheroids formation assay.

Results: The obtained data indicate that miR-7-5p increases the sensitivity of the tested cells to the drug, and that nanoparticles loaded with both miRNA and the drug produce a greater anti-tumor effect in comparison to the free drug treatment. It was found that an increased level of apoptosis in the drug/miRNA co-treated cells is accompanied by an alternation in the expression of the genes encoding for key MDR proteins of the ABC family.

Conclusions: Overall, co-administration of miR-7-5p with a chemotherapeutic can be considered a promising strategy, leading to reduced MDR and the induction of apoptosis in cancer cells.

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Materials
Procduct Name CAS Molecular Formula Supplier Price
Carmustine 154-93-8 C5H9Cl2N3O2 382 suppliers $5.00-$1593.90
Carmustine 154-93-8 C5H9Cl2N3O2 382 suppliers $5.00-$1593.90
Carmustine 154-93-8 C5H9Cl2N3O2 382 suppliers $5.00-$1593.90
Carmustine 154-93-8 C5H9Cl2N3O2 382 suppliers $5.00-$1593.90

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