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Regulatory Toxicology and Pharmacology

Regulatory Toxicology and Pharmacology

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Subchronic (90-Day) repeated dose toxicity study of disodium adenosine-5′-triphosphate in rats

Published:1 October 2020 DOI: 10.1016/j.yrtph.2020.104760 PMID: 32771599
Ralf J?ger , Martin Purpura , John C. Fuller Jr.

Abstract

Adenosine-5′-triphosphate (ATP) is the primary source of energy for cells and oral supplementation with ATP offers numerous different health benefits, including the regulation of blood flow and muscle contraction. In this study, ATP, disodium salt, was administered by gavage to rats for 90 consecutive days at doses of 0 (control), 500, 1000, and 2000?mg?kg BW?1·d?1 (n?=?10 per sex/group). Subchronic administration of ATP was well tolerated at all dose levels. Body weights and feed consumption body weight gains were similar between ATP-treated and control rats. Minor differences were seen in hematology and blood chemistry; however, these changes were not dose related and therefore not of biological or toxicological significance. Only one difference was observed in absolute organ weights, females of the high dose had increased kidney and increased relative kidney and liver weights; however, these differences were not seen in males nor appeared to be dose related. No biological or toxicological significant differences were observed in thyroid function or urine analysis. The incidence of histopathological lesions was low and similar between treated and control groups. Based upon these findings, the no-observed-adverse-effect level (NOAEL) was determined to be?≥?2000?mg?kg BW?1·d?1, which was the highest dose tested.

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Procduct Name CAS Molecular Formula Supplier Price
ATP disodium salt 987-65-5 C10H14N5Na2O13P3 732 suppliers $5.00-$2055.90
Adenosine triphosphate 56-65-5 C10H16N5O13P3 421 suppliers Inquiry
Sodium Monofluorophosphate 10163-15-2 FH3NaO3P 392 suppliers $10.00-$695.00

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