一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> ACS Applied Electronic Materials >>article
ACS Applied Electronic Materials

ACS Applied Electronic Materials

IF: 4.3
Download PDF

Dihydromyricetin inhibits cell proliferation, migration, invasion and promotes apoptosis via regulating miR-21 in Human Cholangiocarcinoma Cells.

Published:29 July 2020 DOI: 10.7150/jca.45970 PMID: 32913463
Lei Chen, Zhou-Sheng Yang, Yang-Zhao Zhou, Yang Deng, Pei Jiang, Sheng-Lan Tan

Abstract

Dihydromyricetin, the most abundant natural flavonoid isolated from Ampelopsis grossedentata, exhibits broad anti-tumor effects. However, the effects of dihydromyricetin on cholangiocarcinoma remain unclear. This study examined the anti-tumor effects of dihydromyricetin in two human cholangiocarcinoma cell lines HCCC9810 and TFK-1, and the underlying mechanism was also investigated. Our study was the first to show that dihydromyricetin significantly inhibited cell proliferation, migration, invasion and promoted apoptosis in cholangiocarcinoma cells. By analyzing the TCGA dataset, we found that expression of miR-21, an oncogene and a potential target of anticancer drugs for cholangiocarcinoma, was upregulated in cholangiocarcinoma tissues compared to paired control tissues. Moreover, dihydromyricetin significantly reduced the expression of miR-21 in a dose-dependent manner. Overexpression of miR-21 remarkably abolished the inhibitory effects of dihydromyricetin on cell proliferation, migration, invasion and abrogated its effect of promoting cell apoptosis in both HCCC9810 and TFK-1 cells. Dihydromyricetin remarkably increased the expression of PTEN and decreased the expression of phosphorylated Akt, while overexpression of miR-21 abrogated the modulation of PTEN/ Akt pathway by dihydromyricetin. Taken together, our study demonstrates that dihydromyricetin inhibits cell proliferation, migration, invasion and promotes apoptosis in cholangiocarcinoma cells via regulating miR-21.

Substances (4)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Dihydromyricetin 27200-12-0 C15H12O8 539 suppliers $5.00-$1559.30
Recombinant Human PTEN 62 suppliers Inquiry
AKT3 (AB-1) POLYCLONAL ANTIBODY 33 suppliers $282.00-$729.00
miR-21 5 suppliers Inquiry

Similar articles

IF:4.5

FMNL3 Promotes Migration and Invasion of Breast Cancer Cells via Inhibiting Rad23B‐Induced Ubiquitination of Twist1

Journal of Cellular Physiology Binggong Zhao, Dong‐Man Ye,etc Published: 25 November 2024
防城港市| 勃利县| 土默特右旗| 南投市| 普陀区| 托里县| 西峡县| 永昌县| 太仆寺旗| 陆川县| 巩留县| 清徐县| 鄱阳县| 临澧县| 阜新| 怀来县| 扶风县| 集安市| 南召县| 永顺县| 修武县| 淮南市| 兴海县| 巴里| 昭苏县| 察隅县| 武汉市| 吉安县| 宁国市| 泾源县| 九江县| 清镇市| 平乡县| 万州区| 清苑县| 开封县| 宁强县| 西丰县| 汝南县| 永丰县| 老河口市|