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Cell Reports Medicine

Cell Reports Medicine

IF: 11.7
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Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk

Published:25 August 2020 DOI: 10.1016/j.xcrm.2020.100076 PMID: 33205069
Mark R Davies,?Michael Martinec,?Robert Walls,?Roman Schwarz,?Gary R Mirams,?Ken Wang,?Guido Steiner,?Andy Surinach,?Carlos Flores,?Thierry Lavé,?Thomas Singer,?Liudmila Polonchuk

Abstract

There is an increasing expectation that computational approaches may supplement existing human decision-making. Frontloading of models for cardiac safety prediction is no exception to this trend, and ongoing regulatory initiatives propose use of high-throughput in?vitro data combined with computational models for calculating proarrhythmic risk. Evaluation of these models requires robust assessment of the outcomes. Using FDA Adverse Event Reporting System reports and electronic healthcare claims data from the Truven-MarketScan US claims database, we quantify the incidence rate of arrhythmia in patients and how this changes depending on patient characteristics. First, we propose that such datasets are a complementary resource for determining relative drug risk and assessing the performance of cardiac safety models for regulatory use. Second, the results suggest important determinants for appropriate stratification of patients and evaluation of additional drug risk in prescribing and clinical support algorithms and for precision health.

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Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
Ibutilide fumarate 122647-32-9 (C20H36N2O3S)2.C4H4O4 265 suppliers $14.00-$1871.10
Ibutilide fumarate 122647-32-9 (C20H36N2O3S)2.C4H4O4 265 suppliers $14.00-$1871.10
Ibutilide fumarate 122647-32-9 (C20H36N2O3S)2.C4H4O4 265 suppliers $14.00-$1871.10
Ibutilide fumarate 122647-32-9 (C20H36N2O3S)2.C4H4O4 265 suppliers $14.00-$1871.10

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