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Nature Communications

Nature Communications

IF: 14.7
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CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer

Published:30 November 2020 DOI: 10.1038/s41467-020-19973-6 PMID: 33257678
Man Zhang, Wei Yang, Peng Wang, Yu Deng, Yu-Ting Dong, Fang-Fang Liu, Rui Huang, Peng Zhang, Ya-Qi Duan, Xin-Dong Liu, Dandan Lin, Qian Chu, Bo Zhong

Abstract

The efficacy of checkpoint immunotherapy to non-small cell lung cancer (NSCLC) largely depends on the tumor microenvironment (TME). Here, we demonstrate that CCL7 facilitates anti-PD-1 therapy for the KrasLSL-G12D/+Tp53fl/fl (KP) and the KrasLSL-G12D/+Lkb1fl/fl (KL) NSCLC mouse models by recruiting conventional DC 1 (cDC1) into the TME to promote T cell expansion. CCL7 exhibits high expression in NSCLC tumor tissues and is positively correlated with the infiltration of cDC1?in the TME and the overall survival of NSCLC patients. CCL7 deficiency impairs the infiltration of cDC1 in the TME and the subsequent expansion of CD8+ and CD4+ T cells in bronchial draining lymph nodes and TME, thereby promoting tumor development in the KP mouse model. Administration of CCL7 into lungs alone or in combination with anti-PD-1 significantly inhibits tumor development and prolongs the survival of KP and KL mice. These findings suggest that CCL7 potentially serves as a biomarker and adjuvant for checkpoint immunotherapy of NSCLC.

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Materials
Procduct Name CAS Molecular Formula Supplier Price
Ruxolitinib phosphate 1092939-17-7 C17H21N6O4P 387 suppliers $15.00-$3546.00
Ruxolitinib phosphate 1092939-17-7 C17H21N6O4P 387 suppliers $15.00-$3546.00
Ruxolitinib phosphate 1092939-17-7 C17H21N6O4P 387 suppliers $15.00-$3546.00
Ruxolitinib phosphate 1092939-17-7 C17H21N6O4P 387 suppliers $15.00-$3546.00

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