一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> ACS Applied Nano Materials >>article
ACS Applied Nano Materials

ACS Applied Nano Materials

IF: 5.3
Download PDF

Preparation, Synergism, and Biocompatibility of in situ Liquid Crystals Loaded with Sinomenine and 5-Fluorouracil for Treatment of Liver Cancer

Published:31 May 2021 DOI: 10.2147/IJN.S207607 PMID: 34103913
Jiaojiao Cao,?Jie Huang,?Shuangying Gui,?Xiaoqin Chu

Abstract

Purpose: Transarterial chemoembolization is the preferred treatment for patients with middle and advanced-stage hepatocellular carcinoma (HCC); however, most hepatic artery embolization agents have various disadvantages. The purpose of this study was to evaluate phytantriol-based liquid crystal injections for potential use in treatment of HCC.

Methods: Using sinomenine (SN) and 5-fluorouracil (5-FU) as model drugs, three precursor in situ liquid crystal injections based on phytantriol (P1, P2, and P3) were prepared, and their in vitro biocompatibility, anticancer activity, and drug release investigated, to evaluate their feasibility for use in treatment of HCC. The properties of the precursor injections and subsequent cubic liquid crystal gels were observed by visual and polarizing microscopy, in an in vitro gelation experiment. Biocompatibility was evaluated by in vitro hemolysis, histocompatibility, and cytotoxicity assays.

Results: Precursor injections were colorless liquids that formed transparent cubic liquid crystal gels on addition of excess water. The three precursor injections all caused slight hemolysis, without agglutination, and were mildly cytotoxic. Histocompatibility experiments showed that P1 had good histocompatibility, while P2 and P3 resulted in strong inflammatory responses, which subsequently resolved spontaneously. In vitro anti-cancer testing showed that SN and 5-FU inhibited HepG2 cells in a time- and concentration-dependent manner and had synergistic effects. Further, in vitro release assays indicated that all three preparations had sustained release effects, with cumulative release of >80% within 48 h.

Conclusion: These results indicate that SN and 5-FU have synergistic inhibitory effects on HepG2 cells, which has not previously been reported. Moreover, we describe a biocompatible precursor injection, useful as a drug carrier for the treatment of liver cancer, which can achieve targeting, sustained release, synergistic chemotherapy, and embolization. These data indicate that precursor injections containing SN and 5-FU have great potential for use in therapy for liver cancer.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Urethane 51-79-6 C3H7NO2 599 suppliers $10.00-$3589.98
Urethane 51-79-6 C3H7NO2 599 suppliers $10.00-$3589.98
Urethane 51-79-6 C3H7NO2 599 suppliers $10.00-$3589.98
Urethane 51-79-6 C3H7NO2 599 suppliers $10.00-$3589.98
Ethyl carbamate 51-79-6 C3H7NO2 - Inquiry
Ethyl carbamate 51-79-6 C3H7NO2 - Inquiry

Similar articles

IF:5.3

Preparation and characterization of Tamoxifen citrate loaded nanoparticles for breast cancer therapy.

ACS Applied Nano Materials Ruma Maji, Niladri Shekhar Dey,etc Published: 25 June 2014
IF:0

Triamcinolone Acetonide and 5-Fluorouracil Intralesional Combination Injection in Keloid Treatment

International Journal of Integrated Health Sciences Jono Hadi Agusni,?Eva Krishna Sutedja,etc Published: 31 March 2017
IF:0

Evaluation of Intralesional Injection of 5-fluorouracil in Treatment of Vitiligo

Journal of Advances in Medicine and Medical Research D. M. Anber,?D. M. Ali,etc Published: 19 March 2021
白朗县| 根河市| 辽源市| 石嘴山市| 高淳县| 祁门县| 兖州市| 义马市| 财经| 资溪县| 石城县| 宜川县| 嘉善县| 体育| 越西县| 鄂托克旗| 腾冲县| 边坝县| 新巴尔虎右旗| 东乡族自治县| 师宗县| 大兴区| 磐石市| 陆河县| 来宾市| 上思县| 赤水市| 西丰县| 永泰县| 乳源| 伊吾县| 百色市| 温泉县| 余姚市| 包头市| 民丰县| 博爱县| 三明市| 南川市| 莱芜市| 庆元县|