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Food & Function

Food & Function

IF: 5.1
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Structural characterization and immunomodulatory activity of a novel polysaccharide from Ficus carica

Published:16 June 2018 DOI: 10.1039/C8FO00603B PMID: 29974087
Juan Du, Jingjing Li, Jianhua Zhu, Chunhua Huang, Sixue Bi, Liyan Song, Xianjing Hu and Rongmin Yu

Abstract

A novel polysaccharide (FCPW80-2) with a molecular weight of 1.21 × 105 Da was first isolated from Ficus carica through hot water extraction and several chromatographic methods. The structure of FCPW80-2 was determined by chemical and instrumental analysis. The results showed that the backbone of FCPW80-2 consists of (1→5)-linked α-L-Ara, (1→3,6)-linked β-D-Man and (1→4,6)-linked β-D-Gal. The branches of FCPW80-2 consist of (1→4)-linked α-D-Glc and (1→3)-linked β-L-Rha terminated with (1→)-linked β-D-Glc. In vitro immunomodulatory activity assays revealed that FCPW80-2 could markedly promote the secretion of cytotoxic molecules (NO) and cytokines (TNF-α and IL-6) as well as the phagocytosis of RAW264.7 macrophages. Moreover, TLR2 was found to be a pattern recognition receptor (PRR) of FCPW80-2, and its related mitogen-activated protein kinases (MAPKs), including p-ERK, p-JNK and p-p38, were rapidly upregulated by FCPW80-2 in RAW264.7 macrophages. Furthermore, FCPW80-2 could not only upregulate the expression of p-p65 and p-IκB-α, but also cause the translocation of nuclear factor-kappa B (NF-κB) p65 from cytosol to nuclei in RAW264.7 macrophages. The results demonstrated that MAPK and NF-κB signalling pathways participated in FCPW80-2-induced macrophage activation and FCPW80-2 could be developed as a potential immunomodulating functional food.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
TLR2-IN-C29 363600-92-4 C16H15NO4 99 suppliers $13.00-$2500.00
TLR2-IN-C29 363600-92-4 C16H15NO4 99 suppliers $13.00-$2500.00
TLR2-IN-C29 363600-92-4 C16H15NO4 99 suppliers $13.00-$2500.00
TLR2-IN-C29 363600-92-4 C16H15NO4 99 suppliers $13.00-$2500.00

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