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Cell Death Discovery

Cell Death Discovery

IF: 6.1
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Upregulation of CPNE7 in mesenchymal stromal cells promotes oral squamous cell carcinoma metastasis through the NF-κB pathway

Published:14 October 2021 DOI: 10.1038/s41420-021-00684-w PMID: 34650058
Xiaoli Ji, Tianyong Sun, Shang Xie, Hua Qian, Lixiang Song, Lihua Wang, Hongwei Liu, Qiang Feng

Abstract

A remarkable shift in Mesenchymal stromal cells (MSCs) plays an important role in cancer metastasis, but the molecular mechanism is still unclear. CPNE7, a calcium-dependent phospholipid-binding protein, mediates signal transduction and metastasis in many tumours. Here, we demonstrated that MSCs derived from OSCC (OSCC-MSCs) promoted the metastasis of OSCC cells by transwell assay and animal models through epithelial to mesenchymal transition (EMT) (p?

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Materials
Procduct Name CAS Molecular Formula Supplier Price
SB 225002 182498-32-4 C13H10BrN3O4 170 suppliers $12.00-$2180.00
SB 225002 182498-32-4 C13H10BrN3O4 170 suppliers $12.00-$2180.00
SB 225002 182498-32-4 C13H10BrN3O4 170 suppliers $12.00-$2180.00
SB 225002 182498-32-4 C13H10BrN3O4 170 suppliers $12.00-$2180.00

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