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Bioactive Materials

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Tropoelastin improves adhesion and migration of intra-articular injected infrapatellar fat pad MSCs and reduces osteoarthritis progression

Published:1 April 2022 DOI: 10.1016/j.bioactmat.2021.09.011 PMID: 34901559
Junjun Yang , Xin Wang , Yahan Fan , Xiongbo Song , Jiangyi Wu , Zhenlan Fu , Tao Li , Yang Huang , ZheXiong Tang , Shuo Meng , Na Liu , Jiajia Chen , Pingju Liu , Liu Yang , Xiaoyuan Gong , Cheng Chen

Abstract

Intra-articular injection of mesenchymal stem cells (MSCs) is a promising strategy for osteoarthritis (OA) treatment. However, more and more studies reveal that the injected MSCs have poor adhesion, migration, and survival in the joint cavity. A recent study shows that tropoelastin (TE) regulates adhesion, proliferation and phenotypic maintenance of MSCs as a soluble additive, indicating that TE could promote MSCs-homing in regenerative medicine. In this study, we used TE as injection medium, and compared it with classic media in MSCs intra-articular injection such as normal saline (NS), hyaluronic acid (HA), and platelet-rich plasma (PRP). We found that TE could effectively improve adhesion, migration, chondrogenic differentiation of infrapatellar fat pad MSCs (IPFP-MSCs) and enhance matrix synthesis of osteoarthritic chondrocytes (OACs) in indirect-coculture system. Moreover, TE could significantly enhance IPFP-MSCs adhesion via activation of integrin β1, ERK1/2 and vinculin (VCL) in vitro. In addition, intra-articular injection of TE-IPFP MSCs suspension resulted in a short-term increase in survival rate of IPFP-MSCs and better histology scores of rat joint tissues. Inhibition of integrin β1 or ERK1/2 attenuated the protective effect of TE-IPFP MSCs suspension in vivo. In conclusion, TE promotes performance of IPFP-MSCs and protects knee cartilage from damage in OA through enhancement of cell adhesion and activation of integrin β1/ERK/VCL pathway. Our ?ndings may provide new insights in MSCs intra-articular injection for OA treatment.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
SCH772984 942183-80-4 C33H33N9O2 173 suppliers $37.00-$2400.00
SCH772984 942183-80-4 C33H33N9O2 173 suppliers $37.00-$2400.00
SCH772984 942183-80-4 C33H33N9O2 173 suppliers $37.00-$2400.00
SCH772984 942183-80-4 C33H33N9O2 173 suppliers $37.00-$2400.00

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